Jasani Reena, Deacon Jennifer W, Sertich Anthony
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Cureus. 2021 Sep 4;13(9):e17719. doi: 10.7759/cureus.17719. eCollection 2021 Sep.
Corticosteroids have several widely documented adverse effects. However, there is no systematic study evaluating the frequency and associations of corticosteroid-induced mania. We report a case of corticosteroid-induced mania in a patient that previously tolerated higher doses of steroid therapy without neuropsychiatric symptoms. Although there is evidence suggesting a dose-dependent relationship, previous tolerance has not been proven to correlate with reduced frequency of developing mania or psychosis on the reintroduction of the medication. Therefore, patients restarting steroids should proceed carefully, even when receiving low doses.
皮质类固醇有多种有广泛文献记载的不良反应。然而，尚无系统性研究评估皮质类固醇所致躁狂的发生率及相关因素。我们报告一例皮质类固醇所致躁狂病例，该患者此前能耐受更高剂量的类固醇治疗且无神经精神症状。尽管有证据表明存在剂量依赖关系，但既往耐受性尚未被证实与再次用药时发生躁狂或精神病的频率降低相关。因此，即使是接受低剂量治疗，重新开始使用类固醇的患者也应谨慎行事。
