Fiset L, Ramsay D, Milgrom P, Weinstein P
Anesth Prog. 1986 Sep-Oct;33(5):225-9.
The effects of 2% lidocaine containing 72 μg epinephrine on fear related arousal were tested using a cross-over design on dental patients fearful of injections and other dental procedures. Heart rate and body movement in the dental operatory were monitored, and subjects' self-reported upset in the Epinephrine condition than in the No-Epinephrine condition (F = 4.8, p = .04), but the clinical significance was negligible. No interaction between initial fear levels and the drug condition could be established. Results suggest that pre-existing dental fear levels may produce greater self-report, behavioral or physiological arousal in the dental operatory than exogenous epinephrine.
采用交叉设计，对害怕注射及其他牙科治疗程序的牙科患者，测试了含72μg肾上腺素的2%利多卡因对恐惧相关唤醒的影响。监测牙科治疗室中的心率和身体活动，结果显示，与无肾上腺素组相比，肾上腺素组受试者自我报告的不适感更强（F = 4.8，p = .04），但其临床意义可忽略不计。无法确定初始恐惧水平与药物状况之间存在交互作用。结果表明，牙科治疗室中，预先存在的牙科恐惧水平可能比外源性肾上腺素引起更强的自我报告、行为或生理唤醒。
