Institute of Physiological Chemistry, University Medical Center Mainz, 55128 Mainz, Germany.
Institute of Physiological Chemistry, University Medical Center Mainz, 55128 Mainz, Germany; Institute of Psychology, Psychiatry & Neuroscience, Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK; The Francis Crick Institute, London NW1 1AT, UK.
Cell. 2021 Oct 14;184(21):5303-5305. doi: 10.1016/j.cell.2021.09.027.
In this issue of Cell, Wang et al. come to the unsettling conclusion that adeno-associated viruses, despite being engineered for glia-specific expression, can become widely active in endogenous neurons, misleading researchers in their quest for efficient conversion of glia into neurons for brain repair.
在本期《细胞》杂志上，Wang 等人得出了一个令人不安的结论：腺相关病毒，尽管被设计用于神经胶质细胞特异性表达，但在体内神经元中也可以广泛激活，这误导了研究人员追求高效地将神经胶质细胞转化为神经元以进行脑修复。
