Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Dev Neurobiol. 2022 Jul;82(5):367-374. doi: 10.1002/dneu.22880. Epub 2022 May 23.
Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia-to-neuron (GtN) conversion emerges as a potential solution for regeneration-based therapeutics. This approach takes advantage of the regenerative ability of resident glial cells to produce new neurons through cell fate reprogramming. Significant progress has been made over the years in this emerging field. However, inappropriate analysis often leads to misleading conclusions that create confusion and hype. In this perspective, we point out the most salient pitfalls associated with some recent studies and provide solutions to prevent them in the future. The goal is to foster healthy development of this promising field and lay a solid cellular foundation for future regeneration-based medicine.
神经元丢失和神经回路的破坏与许多神经疾病有关。一个关键问题是如何重建神经回路以实现功能改善。体内神经胶质向神经元（GtN）转化为再生治疗提供了一种潜在的解决方案。这种方法利用了常驻神经胶质细胞的再生能力，通过细胞命运重编程产生新的神经元。近年来，在这个新兴领域取得了重大进展。然而，不恰当的分析往往会导致误导性的结论，造成混淆和炒作。在这篇观点文章中，我们指出了与最近一些研究相关的最突出的陷阱，并提供了未来防止这些陷阱的解决方案。目标是促进这一有前途的领域的健康发展，并为未来的再生医学奠定坚实的细胞基础。
