Department of Biomedical Science, Faculty of Applied Science, Lincoln University College, Selangor, Malaysia.
Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Biomed Pharmacother. 2021 Dec;144:112328. doi: 10.1016/j.biopha.2021.112328. Epub 2021 Oct 13.
Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identified, which started as excess generation of reactive oxygen species that leads to oxidative stress, inflammation, DNA damage and apoptosis in the liver. Various natural products, plant extracts and oil rich in flavonoids, terpenoids, polyphenols, and phenolic acids were able to minimize oxidative stress by restoring the level of antioxidant enzymes and acting as an anti-inflammatory agent. Likewise, treatment with honey and royal jelly was demonstrated to decrease serum transaminases and scavenge free radicals in the liver after cisplatin administration. Medicinal properties of these natural products have a promising potential as a complementary therapy to counteract cisplatin-induced hepatotoxicity. This review concentrated on the protective role of several natural products, which has been proven in the laboratory findings to combat cisplatin-induced hepatotoxicity.
顺铂是一种有效的铂类抗癌药物，于 1978 年获得美国食品药品监督管理局（FDA）批准。尽管顺铂对实体瘤有优势，但它会对各种组织产生毒性，限制了其临床应用。在顺铂诱导的肝毒性中，已经确定了一些机制，最初是由于活性氧的过度产生导致氧化应激、炎症、DNA 损伤和肝细胞凋亡。各种天然产物、富含类黄酮、萜类化合物、多酚和酚酸的植物提取物和油，通过恢复抗氧化酶的水平和作为抗炎剂，能够最大限度地减少氧化应激。同样，蜂蜜和蜂王浆的治疗被证明可以降低顺铂给药后血清转氨酶并清除肝脏中的自由基。这些天然产物的药用特性具有很大的潜力，可以作为一种补充疗法，对抗顺铂诱导的肝毒性。本综述集中讨论了几种天然产物的保护作用，这些作用已在实验室研究中得到证实，可以对抗顺铂诱导的肝毒性。
