Laboratorio di Geriatria, Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122, Milan, Italy.
Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.
Aging Clin Exp Res. 2022 Mar;34(3):687-690. doi: 10.1007/s40520-021-01993-x. Epub 2021 Oct 16.
This study measured the subclinical frailty of centenarians by looking at the accumulation of their biological abnormalities. For this aim, a biological Frailty Index (FI) was computed in centenarians living in Northern Italy. The median value of the biological FI was 0.33 (interquartile range, IQR 0.28-0.41). The biological FI did not significantly differ between women (0.34, IQR 0.31-0.39) and men (0.32, IQR 0.26-0.43). The biological FI seems to have a narrower distribution compared to clinical FI we previously computed in the same cohort. In conclusion, our study suggests that centenarians benefit from exceptional biological reserves that might be underestimated by clinical appearances.
本研究通过观察百岁老人生物异常的积累来衡量其亚临床虚弱程度。为此，对居住在意大利北部的百岁老人进行了生物脆弱指数（FI）的计算。生物 FI 的中位数为 0.33（四分位距 IQR 0.28-0.41）。女性（0.34，IQR 0.31-0.39）和男性（0.32，IQR 0.26-0.43）的生物 FI 无显著差异。与我们之前在同一队列中计算的临床 FI 相比，生物 FI 的分布似乎更窄。总之，我们的研究表明，百岁老人受益于异常的生物学储备，而这些储备可能被临床外观所低估。
