Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via Pace 9, 20122, Milan, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122, Milan, Italy.
Aging Clin Exp Res. 2019 Nov;31(11):1685-1688. doi: 10.1007/s40520-019-01283-7. Epub 2019 Jul 29.
Frailty has been indicated as a way for capturing biological aging of the individual and Frailty Index (FI) may serve for this purpose. This study designed the FI in a cohort of centenarians, their offspring and control subjects sex- and age-matched with offspring. The FI mean value was 0.47 (SD 0.13) in centenarians, 0.15 (SD 0.12) in their offspring, and 0.22 (SD 0.14) in controls (p < 0.001). The difference between offspring and controls was statistically significant (p = 0.003). The correlation between FI and age was significant in offspring (r = 0.46, p < 0.001), close to significance in controls (r = 0.25, p = 0.08) and not significant in centenarians. Our study confirms that FI is a marker of biological age useful to discriminate different degrees of frailty even at extremely advanced age.
虚弱已被确定为个体生物衰老的一种表现方式，而虚弱指数 (FI) 可能可用于此目的。本研究在百岁老人、他们的后代和与后代性别和年龄匹配的对照受试者中设计了 FI。百岁老人的 FI 平均值为 0.47（SD 0.13），后代为 0.15（SD 0.12），对照组为 0.22（SD 0.14）（p<0.001）。后代和对照组之间的差异具有统计学意义（p=0.003）。FI 与年龄之间的相关性在后代中显著（r=0.46，p<0.001），在对照组中接近显著（r=0.25，p=0.08），在百岁老人中则不显著。我们的研究证实，FI 是生物年龄的标志物，可用于区分不同程度的虚弱，即使在非常高龄时也是如此。
