从 Pleione grandiflora 中发现具有抗炎活性的葡萄糖氧基苄基 2-羟基-2-异丁基琥珀酸酯。
Discovery of glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates with anti-inflammatory activities from Pleione grandiflora.
机构信息
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, People's Republic of China.
College of Landscape Architecture, Fujian Agriculture and Forestry University, Fuzhou 350002, People's Republic of China.
出版信息
Fitoterapia. 2021 Nov;155:105062. doi: 10.1016/j.fitote.2021.105062. Epub 2021 Oct 14.
Six new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates, pleionesides A-F (1-6), along with two known compounds (7, 8) were obtained from the pseudobulbs of Pleione grandiflora (Rolfe) Rolfe. The structures and absolute configurations of new compounds were established by HRESIMS and NMR data, along with acidic hydrolysis and alkaline hydrolysis experiments. Compounds 1-6 were tested for their anti-inflammatory activities on LPS-induced BV2 microglial cells. Amoung them, 2, 4 and 5 showed moderate activities with IC values of 73.4, 32.8 and 57.1 μM, respectively, compared with the positive control quercetin with an IC value of 28.3 μM.
从 Pleione grandiflora (Rolfe) Rolfe 的假鳞茎中分离得到了 6 个新的葡萄糖氧基苄基 2-羟基-2-异丁基琥珀酸酯，即 pleioneside A-F（1-6），以及两个已知化合物（7、8）。通过高分辨质谱和 NMR 数据以及酸性水解和碱性水解实验确定了新化合物的结构和绝对构型。测试了化合物 1-6 对 LPS 诱导的 BV2 小胶质细胞的抗炎活性。其中，化合物 2、4 和 5 表现出中等活性，IC 值分别为 73.4、32.8 和 57.1 μM，与阳性对照槲皮素（IC 值为 28.3 μM）相比。
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