Department of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Rua Silva Jardim, 136, Santos, SP, 11015-020, Brazil.
Department of Human Movement Science, Federal University of São Paulo, Campus Baixada Santista, Rua Silva Jardim, 136, Santos, SP, 11015-020, Brazil.
Adv Rheumatol. 2021 Oct 16;61(1):62. doi: 10.1186/s42358-021-00220-5.
The knee osteoarthritis (OA) is a joint disease characterized by degradation of articular cartilage that leads to chronic inflammation. Exercise programs and photobiomodulation (PBM) are capable of modulating the inflammatory process of minimizing functional disability related to knee OA. However, their association on the concentration of biomarkers related to OA development has not been studied yet. The aim of the present study is to investigate the effects of PBM (via cluster) with a physical exercise program in functional capacity, serum inflammatory and cartilage degradation biomarkers in patients with knee OA.
Forty-two patients were randomly allocated in 3 groups: ESP: exercise + sham PBM; EAP: exercise + PBM and CG: control group. Six patients were excluded before finished the experimental period. The analyzed outcomes in baseline and 8-week were: the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) and the evaluation of serum biomarkers concentration (IL-1β, IL-6, IL-8, IL-10 e TNF-α, and CTX-II).
An increase in the functional capacity was observed in the WOMAC total score for both treated groups (p < 0.001) and ESP presents a lower value compared to CG (p < 0.05) the 8-week post-treatment. In addition, there was a significant increase in IL-10 concentration of EAP (p < 0.05) and higher value compared to CG (p < 0.001) the 8-week post-treatment. Moreover, an increase in IL-1β concentration was observed for CG (p < 0.05). No other difference was observed comparing the other groups.
Our data suggest that the physical exercise therapy could be a strategy for increasing functional capacity and in association with PBM for increasing IL-10 levels in OA knee individuals.
ReBEC (RBR-7t6nzr).
膝骨关节炎（OA）是一种以关节软骨降解为特征的关节疾病，导致慢性炎症。运动方案和光生物调节（PBM）能够调节炎症过程，最大限度地减少与膝骨关节炎相关的功能障碍。然而，它们对与 OA 发展相关的生物标志物浓度的联合作用尚未得到研究。本研究旨在探讨 PBM（通过集群）与运动方案联合应用对膝骨关节炎患者的功能能力、血清炎症和软骨降解生物标志物的影响。
42 名患者被随机分为 3 组：ESP：运动+假 PBM；EAP：运动+PBM；CG：对照组。有 6 名患者在实验结束前被排除。基线和 8 周时分析的结果是：西安大略和麦克马斯特大学骨关节炎（WOMAC）和血清生物标志物浓度（IL-1β、IL-6、IL-8、IL-10 和 TNF-α，以及 CTX-II）的评估。
治疗组的 WOMAC 总评分均显示功能能力增加（p<0.001），ESP 在 8 周治疗后与 CG 相比具有较低的值（p<0.05）。此外，EAP 的 IL-10 浓度显著增加（p<0.05），且在 8 周治疗后与 CG 相比具有更高的值（p<0.001）。此外，CG 观察到 IL-1β 浓度增加（p<0.05）。其他组之间没有观察到其他差异。
我们的数据表明，运动疗法可能是增加功能能力的一种策略，并与 PBM 联合应用可增加 OA 膝关节患者的 IL-10 水平。
ReBEC（RBR-7t6nzr）。
