Dokmak Amr, Trivedi Hirsh D, Bonder Alan, Wolf Jacqueline
Department of Hospital Medicine, Catholic Medical Center, Manchester, NH, USA.
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Ann Hepatol. 2021 Dec;26:100557. doi: 10.1016/j.aohep.2021.100557. Epub 2021 Oct 14.
Chronic liver disease poses various challenges for women of reproductive age. Cirrhosis, particularly if decompensated, and liver transplantation may impact gestation and perinatal outcomes. Tailored management of underlying liver disease is critical to optimize maternal and fetal wellbeing. Early education, timely intervention, close monitoring, and a multidisciplinary approach are key elements required to minimize complications and increase chances of a safe and successful pregnancy. In this review, we focus on the pregnancy-related implications of chronic liver disease and liver transplantation on women of reproductive age and highlight disease-specific management considerations.
慢性肝病给育龄女性带来了各种挑战。肝硬化，尤其是失代偿期肝硬化，以及肝移植可能会影响妊娠和围产期结局。对基础肝病进行个性化管理对于优化母婴健康至关重要。早期教育、及时干预、密切监测以及多学科方法是将并发症降至最低并增加安全成功妊娠几率所需的关键要素。在本综述中，我们重点关注慢性肝病和肝移植对育龄女性与妊娠相关的影响，并强调特定疾病的管理注意事项。
