Kobryn Eliza, Jabiry-Zieniewicz Zoulikha, Akpang Nicole, Zieniewicz Krzysztof, Grat Michal, Ludwin Artur, Szpotanska-Sikorska Monika
1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland.
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland.
Diagnostics (Basel). 2025 Aug 16;15(16):2054. doi: 10.3390/diagnostics15162054.
: Pre-pregnancy overweight and obesity are established risk factors for adverse maternal and perinatal outcomes in the general obstetric population. However, data regarding their impact in female liver transplant recipients remain limited. This study aimed to evaluate the association between pre-pregnancy body mass index (BMI) and pregnancy-related complications and neonatal outcomes in this high-risk cohort. : A retrospective cohort analysis was conducted on pregnancies in liver transplant recipients who delivered between 2001 and 2022 at a single tertiary referral center. Participants were stratified into two groups based on pre-pregnancy BMI: normal weight (18.5-24.9 kg/m) and overweight/obese (≥25 kg/m). Maternal characteristics, pregnancy complications, and perinatal outcomes were compared using appropriate statistical methods, with significance set at < 0.05. : Among 72 pregnancies included in the analysis, 48 (66.7%) were in women with normal BMI, and 24 (33.3%) were in those with an elevated BMI. No statistically significant differences were observed in gestational age at delivery, neonatal birth weight, Apgar scores, or incidence of preterm birth. Although pregnancy-induced hypertension and cesarean delivery were more prevalent among overweight/obese individuals, these differences did not reach statistical significance (PIH: 28% vs. 10.4%, = 0.112; cesarean delivery: 76% vs. 64.6%, = 0.465). : In conclusion, pre-pregnancy overweight and obesity were not significantly associated with adverse obstetric or neonatal outcomes in liver transplant recipients. Nevertheless, the observed trends suggest a potential predisposition to hypertensive disorders (PIH: 28% vs. 10.4%, = 0.112), underscoring the importance of individualized preconception counseling and weight optimization strategies in this high-risk patient population.
孕前超重和肥胖是普通产科人群不良孕产妇和围产期结局的既定风险因素。然而，关于它们对女性肝移植受者影响的数据仍然有限。本研究旨在评估该高危队列中孕前体重指数（BMI）与妊娠相关并发症及新生儿结局之间的关联。
对2001年至2022年在单一三级转诊中心分娩的肝移植受者的妊娠情况进行了回顾性队列分析。参与者根据孕前BMI分为两组：正常体重（18.5 - 24.9 kg/m²）和超重/肥胖（≥25 kg/m²）。使用适当的统计方法比较孕产妇特征、妊娠并发症和围产期结局，显著性设定为<0.05。
在纳入分析的72例妊娠中，48例（66.7%）为BMI正常的女性，24例（33.3%）为BMI升高的女性。在分娩孕周、新生儿出生体重、阿氏评分或早产发生率方面未观察到统计学显著差异。尽管妊娠高血压和剖宫产在超重/肥胖个体中更为普遍，但这些差异未达到统计学显著性（妊娠高血压：28%对10.4%，P = 0.112；剖宫产：76%对64.6%，P = 0.465）。
总之，孕前超重和肥胖与肝移植受者不良产科或新生儿结局无显著关联。然而，观察到的趋势表明存在患高血压疾病的潜在易感性（妊娠高血压：28%对10.4%，P = 0.112），强调了在这一高危患者群体中进行个体化孕前咨询和体重优化策略的重要性。
