Organelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.
J Mol Med (Berl). 2022 Jan;100(1):1-21. doi: 10.1007/s00109-021-02150-7. Epub 2021 Oct 16.
Mitochondria are essential organelles that play a significant role in various cellular processes apart from providing energy in eukaryotic cells. An intricate link between mitochondrial structure and function is now unequivocally accepted. Several molecular players have been identified, which are important in maintaining the structure of the organelle. Dynamin-related protein 1 (DRP1) is one such conserved protein that is a vital regulator of mitochondrial dynamics. Multidisciplinary studies have helped elucidate the structure of the protein and its mechanism of action in great detail. Mutations in various domains of the protein have been identified that are associated with debilitating conditions in patients. The involvement of the protein in disease conditions such as neurodegeneration, cancer, and cardiovascular disorders is also gaining attention. The purpose of this review is to highlight recent findings on the role of DRP1 in human disease conditions and address its importance as a therapeutic target.
线粒体是真核细胞中除了提供能量之外，还在各种细胞过程中发挥重要作用的必需细胞器。线粒体结构和功能之间的复杂联系现在已经得到明确的认可。已经确定了几种分子参与者，它们对于维持细胞器的结构很重要。与 DRP1 相关的蛋白 1（DRP1）是一种保守蛋白，是线粒体动力学的重要调节剂。多学科研究有助于详细阐明该蛋白的结构及其作用机制。已经确定该蛋白的各个结构域中的突变与患者的衰弱状况有关。该蛋白在神经退行性疾病、癌症和心血管疾病等疾病状况中的作用也引起了关注。本综述的目的是强调 DRP1 在人类疾病状况中的作用的最新发现，并探讨其作为治疗靶标的重要性。
