Guney Gurhan, Taskin Mine Islimye, Baykan Ozgur, Adali Ertan, Gul Tezcan Selin, Sarikaya Serkan, Kaya Cihan, Tolu Ezgi
Department of Reproductive Endocrinology and Infertility, Medical Faculty, Balikesir University, Çağıș Campus, 10145 Balıkesir, Turkey.
Department of Reproductive Endocrinology and Infertility, Medical Faculty, Balikesir University, Balıkesir, Turkey.
Ther Adv Endocrinol Metab. 2021 Oct 8;12:20420188211049607. doi: 10.1177/20420188211049607. eCollection 2021.
Polycystic ovary syndrome is known to be the most common hormonal disorder in women of reproductive age. Current evidence shows that regulatory proteins secreted from the adipose tissue called adipokines may have a role in polycystic ovary syndrome. We planned to investigate the role of endotrophin that has never been researched in polycystic ovary syndrome before and its correlation with other metabolic parameters and adipokines such as adiponectin and ghrelin in patients with polycystic ovary syndrome.
Forty-three women (: 43) with polycystic ovary syndrome and 43 (: 43) women as a control group were enrolled in this cross-sectional study. Serum levels of endotrophin, adiponectin, and ghrelin levels were measured with the enzyme-linked immunosorbent assay method. High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol levels, luteinizing hormone/follicle-stimulating hormone ratio, total testosterone, and triglyceride levels were measured. Homeostasis model assessment for insulin resistance index, body mass index, Ferriman Gallwey Score, and waist-to-hip ratio were also evaluated.
Total testosterone, homeostasis model assessment for insulin resistance, C-reactive protein, luteinizing hormone/follicle-stimulating hormone ratio, and triglyceride levels were higher in patients with polycystic ovary syndrome ( < 0.01). No difference was detected between the groups in terms of body mass index, Ferriman Gallwey Score, waist-to-hip ratio, total cholesterol, low-density lipoprotein, and high-density lipoprotein levels ( > 0.05). We did not observe any significant difference in adiponectin and ghrelin levels between the groups ( > 0.05). Patients with polycystic ovary syndrome had significantly higher endotrophin levels ( < 0.01). According to our regression analyses [area under the curve: 0.973 (0.935-1.000), 95% confidence interval, 95.2% sensitivity, and 100% specificity], it was shown that endotrophin greater than 92 ng/ml and homeostasis model assessment for insulin resistance greater than 2.5 might be good predictors for polycystic ovary syndrome diagnosis.
We demonstrated that endotrophin level is higher in patients with polycystic ovary syndrome and may have predicted polycystic ovary syndrome with increased homeostasis model assessment for insulin resistance index. There was no significant difference in adiponectin and ghrelin levels in the polycystic ovary syndrome group. Endotrophin may have a role in polycystic ovary syndrome etiology rather than other adipokines.
多囊卵巢综合征是育龄女性中最常见的激素紊乱疾病。目前的证据表明，脂肪组织分泌的称为脂肪因子的调节蛋白可能在多囊卵巢综合征中起作用。我们计划研究此前从未在多囊卵巢综合征中研究过的内托芬的作用，以及它与多囊卵巢综合征患者其他代谢参数和脂联素、胃饥饿素等脂肪因子的相关性。
本横断面研究纳入了43例多囊卵巢综合征女性（年龄43岁）和43例女性作为对照组。采用酶联免疫吸附测定法测量血清内托芬、脂联素和胃饥饿素水平。测量高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇水平以及黄体生成素/卵泡刺激素比值、总睾酮和甘油三酯水平。还评估了胰岛素抵抗指数的稳态模型评估、体重指数、费里曼-盖尔韦评分以及腰臀比。
多囊卵巢综合征患者的总睾酮、胰岛素抵抗的稳态模型评估、C反应蛋白、黄体生成素/卵泡刺激素比值和甘油三酯水平更高（P＜0.01）。两组在体重指数、费里曼-盖尔韦评分、腰臀比、总胆固醇、低密度脂蛋白和高密度脂蛋白水平方面未检测到差异（P＞0.05）。我们未观察到两组之间脂联素和胃饥饿素水平有任何显著差异（P＞0.05）。多囊卵巢综合征患者的内托芬水平显著更高（P＜0.01）。根据我们的回归分析[曲线下面积：0.973（0.935 - 1.000），95%置信区间，95.2%敏感性和100%特异性]，结果显示内托芬大于92 ng/ml以及胰岛素抵抗的稳态模型评估大于2.5可能是多囊卵巢综合征诊断的良好预测指标。
我们证明多囊卵巢综合征患者的内托芬水平更高，并且随着胰岛素抵抗指数的稳态模型评估增加，内托芬可能预测多囊卵巢综合征。多囊卵巢综合征组中脂联素和胃饥饿素水平无显著差异。内托芬可能在多囊卵巢综合征的病因中起作用，而非其他脂肪因子。
