Zajączkowska Żaneta, Akutko Katarzyna, Kváč Martin, Sak Bohumil, Szydłowicz Magdalena, Hendrich Andrzej B, Iwańczak Barbara, Kicia Marta
Department of Biology and Medical Parasitology, Wrocław Medical University, Wrocław, Poland.
Department and Clinic of Paediatrics, Gastroenterology and Nutrition, Wrocław Medical University, Wrocław, Poland.
Front Med (Lausanne). 2021 Sep 30;8:741751. doi: 10.3389/fmed.2021.741751. eCollection 2021.
Patients with inflammatory bowel disease (IBD) are susceptible to intestinal opportunistic infections due to both defective mucosal immunity and altered immune response resulting from immunosuppressive treatment. Microsporidia infecting the gastrointestinal tract and causing diarrhoea can potentially affect the course of IBD. Stool samples (90 IBD children and 121 healthy age-matched controls) were screened for spp. and by microscopy and polymerase chain reaction followed by sequencing. genotype D was found in seven out of 90 (7.8%) IBD children. No children from the control group were infected, making the pathogen prevalence in the IBD group significant ( = 0.002). Furthermore, infection was confirmed only in patients receiving immunosuppressive treatment ( = 0.013). Children with IBD are at risk of intestinal infection, especially when receiving immunosuppressive treatment. Therefore, microsporidia should be considered as a significant infectious agent in this group of patients.
炎症性肠病（IBD）患者由于黏膜免疫缺陷以及免疫抑制治疗导致的免疫反应改变，易发生肠道机会性感染。感染胃肠道并引起腹泻的微孢子虫可能会影响IBD的病程。对粪便样本（90名IBD儿童和121名年龄匹配的健康对照）进行显微镜检查和聚合酶链反应，随后进行测序，以筛查微孢子虫属和种。在90名（7.8%）IBD儿童中，有7名发现基因型D。对照组儿童均未感染，IBD组病原体患病率显著（P = 0.002）。此外，仅在接受免疫抑制治疗的患者中确诊感染（P = 0.013）。IBD儿童有肠道微孢子虫感染风险，尤其是在接受免疫抑制治疗时。因此，微孢子虫应被视为该组患者的重要感染病原体。
