Zheng Xiuli, Bian Shuaishuai, Liu Weimin, Zhang Chuangli, Wu Jiasheng, Ren Haohui, Zhang Wenjun, Lee Chun-Sing, Wang Pengfei
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
ACS Omega. 2021 Sep 28;6(40):26575-26582. doi: 10.1021/acsomega.1c03947. eCollection 2021 Oct 12.
The design and synthesis of single-molecule amphiphilic and multifunctional phototherapeutic agents are important to cancer diagnosis and therapy. In this work, we developed three amphiphilic diketopyrrolopyrrole derivatives (TPADPP, DTPADPP, and TPADDPP) with different donor-acceptor structures and poly(ethylene glycol) side chains. The corresponding nanoparticles (NPs) were obtained via a self-assembly from three amphiphilic DPP derivatives and used as smart phototherapeutic agents for tumor diagnosis and treatment. The three amphiphilic DPP NPs exhibited near-infrared (NIR) emissions and good biocompatibility. Thus, they could be used as fluorescence (FL) imaging agents for guided therapy. DTPADPP NPs and TPADDPP NPs also displayed excellent photothermal performance and high accumulation in the tumor. Owing to these beneficial features, the DTPADPP NPs and TPADDPP NPs synthesized herein are suitable for NIR FL imaging and effective photothermal therapy against the tumor .
单分子两亲性多功能光治疗剂的设计与合成对癌症诊断和治疗具有重要意义。在这项工作中，我们开发了三种具有不同供体-受体结构和聚乙二醇侧链的两亲性二酮吡咯并吡咯衍生物（TPADPP、DTPADPP和TPADDPP）。通过三种两亲性DPP衍生物的自组装获得了相应的纳米颗粒（NPs），并将其用作肿瘤诊断和治疗的智能光治疗剂。这三种两亲性DPP NPs表现出近红外（NIR）发射和良好的生物相容性。因此，它们可用作引导治疗的荧光（FL）成像剂。DTPADPP NPs和TPADDPP NPs还表现出优异的光热性能和在肿瘤中的高积累。由于这些有益特性，本文合成的DTPADPP NPs和TPADDPP NPs适用于近红外FL成像和针对肿瘤的有效光热治疗。
