Thakur Mayank, Weng Alexander, Fuchs Hendrik, Sharma Vikas, Bhargava Chandra Shekhar, Chauhan Nagendra S, Dixit Vinod K, Bhargava Shilpi
Institute for Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Germany; Advance Institute of Biotech and Paramedical Sciences, Naramau, Kanpur (U.P.) 208002, India; Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar (M.P.) 470003, India.
Institute for Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Germany.
Carbohydr Polym. 2012 Jan 4;87(1):3-15. doi: 10.1016/j.carbpol.2011.08.035. Epub 2011 Aug 23.
Rasayana constitutes a very important class of Ayurvedic herbs, which acts as rejuvenators and tonic. Despite intensive research on evaluating the medicinal basis for the purported medical benefits of Rasayana herbs, still a specific chemical guiding principle for the characterization of these herbs in one single category is unclear. Here we explore the possibility that polysaccharides play a key role in Rasayana properties exhibited by medicinal plants. Further on this could be a possible field for exploration for a common factor present in some of the Ayurvedic herbs. The present review covers a literature spanning from 1956 to 2011. Some translations of traditional Ayurvedic texts dating back to the first century AD have been referred to as well. In our assessment of the present literature and studies carried out it is presupposed that the presence of benevolent plant polysaccharides must be one of the important features symbolizing a common effectiveness in most of the Ayurvedic Rasayana herbs. Of the many plant metabolites polysaccharides have not so far been considered and studied effectively compared to other secondary metabolites like saponins, alkaloids, etc. Although all the results reported until now suggest a major contribution of polysaccharide towards the maintenance of physiological homeostasis, which is the guiding principle of Rasayana therapy. The present review is an attempt to find a connective link between the concept of Rasayana and well-being; and the role of plant polysaccharides. Lack of clinical information on number of polysaccharides showing promise is a limiting factor for a complete understanding. It is also important to carry out a molecular interaction study to understand the behavior of polysaccharides discussed in the present review.
rasayana是阿育吠陀草药中非常重要的一类，具有 rejuvenators和滋补剂的作用。尽管对rasayana草药所谓的医学益处的药用基础进行了深入研究，但目前仍不清楚将这些草药归为同一类别的具体化学指导原则。在这里，我们探讨了多糖在药用植物表现出的rasayana特性中起关键作用的可能性。进一步而言，这可能是探索某些阿育吠陀草药中存在的共同因素的一个潜在领域。本综述涵盖了1956年至2011年的文献。还参考了一些可追溯到公元一世纪的传统阿育吠陀文本的翻译。在我们对现有文献和研究的评估中，假定仁慈的植物多糖的存在必定是大多数阿育吠陀rasayana草药中象征共同功效的重要特征之一。与皂苷、生物碱等其他次生代谢产物相比，在众多植物代谢产物中，多糖至今尚未得到有效考虑和研究。尽管目前报道的所有结果都表明多糖对维持生理稳态有重要贡献，而生理稳态是rasayana疗法的指导原则。本综述旨在寻找rasayana概念与健康之间的联系；以及植物多糖的作用。缺乏关于显示出前景的多糖数量的临床信息是全面理解的一个限制因素。开展分子相互作用研究以了解本综述中讨论的多糖的行为也很重要。
