Wang Huifei, Yang Mengwan, Wang Yuting, Man Xi, Lu Xinyao, Mou Zehuai, Luo Yunjie, Liang Hongze
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Org Lett. 2021 Nov 5;23(21):8183-8188. doi: 10.1021/acs.orglett.1c02893. Epub 2021 Oct 19.
A nickel-catalyzed reductive cross coupling with phosphonium salts and allylic C(sp)-O bond electrophiles, which granted direct construction of the C(sp)-C(sp) bond, is successfully developed. The protocol features broad substrate scope, high-functional-group tolerance, and heterocycle compatibility. Notably, the much more challenging reductive cross coupling with heterocyclic thiazolylphosphonium salts has also been accomplished for the first time.
成功开发了一种镍催化的与鏻盐和烯丙基C(sp)-O键亲电试剂的还原交叉偶联反应，该反应可直接构建C(sp)-C(sp)键。该方法具有底物范围广、官能团耐受性高和杂环兼容性好的特点。值得注意的是，首次实现了与杂环噻唑基鏻盐更具挑战性的还原交叉偶联反应。
