Division of Gynecology and Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Department of Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(Suppl 1):123-134. doi: 10.1002/ijgo.13870.
Despite the evidence supporting the relevance of obesity and obesity-associated disorders in the development, management, and prognosis of various cancers, obesity rates continue to increase worldwide. Growing evidence supports the involvement of obesity in the development of gynecologic malignancies. This article explores the molecular basis governing the alteration of hallmarks of cancer in the development of obesity-related gynecologic malignancies encompassing cervical, endometrial, and ovarian cancers. We highlight specific examples of how development, management, and prognosis are affected for each cancer, incorporate current knowledge on complementary approaches including lifestyle interventions to improve patient outcomes, and highlight how new technologies are helping us better understand the biology underlying this neglected pandemic.
尽管有证据表明肥胖症和与肥胖相关的疾病与各种癌症的发生、治疗和预后有关，但肥胖率仍在全球范围内持续上升。越来越多的证据支持肥胖症与妇科恶性肿瘤的发生有关。本文探讨了肥胖相关妇科恶性肿瘤（包括宫颈癌、子宫内膜癌和卵巢癌）发生过程中控制癌症标志性变化的分子基础。我们重点介绍了每种癌症的发展、治疗和预后受影响的具体实例，纳入了改善患者预后的生活方式干预等补充方法的现有知识，并强调了新技术如何帮助我们更好地理解这一被忽视的大流行病的生物学基础。
