Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
World J Gastroenterol. 2024 Mar 7;30(9):1043-1072. doi: 10.3748/wjg.v30.i9.1043.
Several diseases originate from bile duct pathology. Despite studies on these diseases, certain etiologies of some of them still cannot be concluded. The most common disease of the bile duct in newborns is biliary atresia, whose prognosis varies according to the age of surgical correction. Other diseases such as Alagille syndrome, inspissated bile duct syndrome, and choledochal cysts are also time-sensitive because they can cause severe liver damage due to obstruction. The majority of these diseases present with cholestatic jaundice in the newborn or infant period, which is quite difficult to differentiate regarding clinical acumen and initial investigations. Intraoperative cholangiography is potentially necessary to make an accurate diagnosis, and further treatment will be performed synchronously or planned as findings suggest. This article provides a concise review of bile duct diseases, with interesting cases.
几种疾病源于胆管病变。尽管对这些疾病进行了研究，但其中某些疾病的某些病因仍无法确定。新生儿胆管最常见的疾病是胆道闭锁，其预后取决于手术矫正的年龄。其他疾病，如 Alagille 综合征、浓缩胆管综合征和胆总管囊肿，也与时间有关，因为它们会因梗阻而导致严重的肝损伤。这些疾病中的大多数在新生儿或婴儿期表现为胆汁淤积性黄疸，由于临床敏锐度和初步检查，很难对其进行区分。术中胆管造影术对于做出准确诊断可能是必要的，并且将根据发现同步进行或计划进一步治疗。本文提供了一个关于胆管疾病的简明综述，并介绍了一些有趣的病例。
