Centre for Host Microbiome Interaction (CHMI), Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.
Department of Periodontology, Centre for Host-Microbiome Interactions (CHMI), Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, Guy's Hospital, London, UK.
Clin Exp Dermatol. 2022 Mar;47(3):522-528. doi: 10.1111/ced.14987. Epub 2021 Dec 22.
For several decades, there has been a significant growth in the incidence of autoimmune diseases. Studies indicate that genetic factors may not be the only trigger for disease development and that dysbiosis of the microbiome may be another mechanism involved in the pathogenesis of autoimmune diseases. The role of the microbiome in the development of common skin disorders such as psoriasis, atopic dermatitis, acne and rosacea is increasingly well understood. However, few studies have focused on lichen planus and the rare acquired immunobullous diseases, both mucocutaneous groups of disorders linked to skin, oral and gut microbiomes. This review provides an insight into the current understanding of how the microbiome may contribute to the development of autoimmunity and to the maintenance and exacerbation of acquired immunobullous and lichenoid diseases. These mechanisms may have implications for future preventive and therapeutic approaches.
几十年来，自身免疫性疾病的发病率显著上升。研究表明，遗传因素可能不是疾病发展的唯一诱因，微生物组的失调也可能是参与自身免疫性疾病发病机制的另一种机制。微生物组在常见皮肤疾病（如银屑病、特应性皮炎、痤疮和酒渣鼻）的发展中的作用越来越被理解。然而，很少有研究关注扁平苔藓和罕见的获得性免疫性大疱病，这两种黏膜皮肤疾病群都与皮肤、口腔和肠道微生物组有关。本综述提供了对微生物组如何有助于自身免疫的发展以及获得性免疫性大疱病和扁平苔藓样疾病的维持和加重的现有理解。这些机制可能对未来的预防和治疗方法具有重要意义。
