ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey (Ms Wojcik, Ms Gallagher, Dr Alexander, and Dr Lewis).
J Occup Environ Med. 2022 Mar 1;64(3):250-262. doi: 10.1097/JOM.0000000000002416.
To describe mortality trends of men and women working in various petrochemical and refinery operations of a U.S.-based company.
The cohort consists of full-time employees with at least 1 day of service during 1979 through 2010. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) were calculated for 111 possible causes of death studied.
SMRs for malignant mesothelioma and asbestosis were highest for the 1940s decade of hire. Increased SMRs were observed for malignant melanoma and motor neuron disease with no obvious work patterns. Decreasing mortality patterns were observed for aplastic anemia and acute nonlymphocytic leukemia.
Mortality surveillance of this large established cohort aids in assessing the chronic health status of the workforce. Identifying methods for incorporating job-exposure matrices and nonoccupational risk factors could further enhance interpretations for some findings such as motor neuron disease.
描述一家美国公司从事各种石化和炼油作业的男性和女性员工的死亡率趋势。
该队列由 1979 年至 2010 年期间至少有 1 天服务的全职员工组成。为研究的 111 种可能的死亡原因计算了标准化死亡率（SMR）和 95%置信区间（CI）。
入职的 20 世纪 40 年代，恶性间皮瘤和石棉沉着病的 SMR 最高。未发现明显的工作模式，但恶性黑色素瘤和运动神经元病的 SMR 升高。再生障碍性贫血和急性非淋巴细胞白血病的死亡率呈下降趋势。
对这个大型既定队列进行死亡率监测有助于评估劳动力的慢性健康状况。确定结合职业暴露矩阵和非职业风险因素的方法可以进一步增强对某些发现的解释，例如运动神经元病。
