南亚发展中国家家禽中耐黏菌素情况
Prevalence of Colistin-Resistant from Poultry in South Asian Developing Countries.
作者信息
Dawadi Prabin, Bista Shrijana, Bista Sayara
机构信息
Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal.
Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
出版信息
Vet Med Int. 2021 Oct 11;2021:6398838. doi: 10.1155/2021/6398838. eCollection 2021.
BACKGROUND
Antimicrobial resistance has become a huge problem in animal and public health worldwide. Inadvertent use of antibiotics in poultry has led to the emergence of resistance against many antibiotics, even to last resort of drugs like colistin.
AIM
This study aimed to provide uniform quantitative estimate on the percentage prevalence of . as well as to analyze their colistin resistance in poultry in South Asian developing countries.
METHODS
Two electronic databases, PubMed and Research4Life, were used to search studies as per the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The pooled data on the prevalence of . and colistin resistance were analyzed.
RESULTS
In the meta-analysis of 9 studies in South Asian region (Nepal, Bangladesh, Pakistan, and India), the pooled prevalence of . was 73% (95% CI, 0.549-0.916). The pooled prevalence of colistin resistance against . from poultry was found to be 28% (95% CI, 0.158-0.438).
CONCLUSION
There is high prevalence of . and their resistance rate against colistin in poultry. Therefore, antimicrobials in raising livestock should be supervised.
背景
抗菌药物耐药性已成为全球动物和公共卫生领域的一个巨大问题。家禽中抗生素的不当使用导致了对许多抗生素产生耐药性，甚至对黏菌素等最后手段药物也产生了耐药性。
目的
本研究旨在对南亚发展中国家家禽中[具体细菌名称未给出]的流行率提供统一的定量估计，并分析它们对黏菌素的耐药性。
方法
按照系统评价和Meta分析的首选报告项目（PRISMA）指南，使用两个电子数据库PubMed和Research4Life检索研究。对[具体细菌名称未给出]的流行率和黏菌素耐药性的汇总数据进行了分析。
结果
在对南亚地区（尼泊尔、孟加拉国、巴基斯坦和印度）9项研究的Meta分析中，[具体细菌名称未给出]的汇总流行率为73%（95%可信区间，0.549 - 0.916）。在家禽中对[具体细菌名称未给出]的黏菌素耐药性汇总流行率为28%（95%可信区间，0.158 - 0.438）。
结论
家禽中[具体细菌名称未给出]的流行率很高，且它们对黏菌素的耐药率也很高。因此，应监督家畜饲养中抗菌药物的使用。
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