Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Department of Microbiology and Public Health, Faculty of Veterinary, Animal and Biomedical Sciences, Khulna Agricultural University, Khulna 9100, Bangladesh.
Biomed Res Int. 2023 Feb 1;2023:2425564. doi: 10.1155/2023/2425564. eCollection 2023.
Antimicrobial resistance (AMR) is a significant public health issue in Bangladesh like many other developing countries where data on resistance trends are scarce. Moreover, the existence of multidrug-resistant (MDR) exerts an ominous effect on the poultry sector. Therefore, the current systematic review, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was conducted to find out the AMR scenarios in isolates sourced from poultry and poultry environments in Bangladesh between 2010 and 2021. Following the PRISMA guidelines, a total of 17 published scientific articles were selected for this systematic review. This review revealed that 18 out of 64 districts in Bangladesh reported in poultry, having a higher prevalence (combined prevalence: 69.3%, 95% confidence interval, CI: 67.3-71%). Moreover, the prevalence ranged from 24.3% to 100%. This review found that isolates showed resistance to 14 antimicrobial classes and 45 different antimicrobial agents, including the last-line (reserve group) antibiotics and banned antimicrobial categories for the treatment of infections in agricultural animals. Phenotypic resistance of against penicillins and beta-lactamase inhibitors (20.2%-100%), cephalosporins (1.9%-100%), fluoroquinolones (5.98%-100%), aminoglycosides (6%-100%), tetracyclines (17.7%-100%), carbapenems (13.6%-72.7%), macrolides (11.8%-100%), polymyxins (7.9%-100%), phenicols (20%-97.2%), sulfa drugs (44.7%-100%), cephamycins (21.4%-48.8%), nitrofurans (21.4%-63.2%), monobactams (1.2%), and glycylcyclines (2.3%) was recorded in the last decades in Bangladesh. Also, 14 articles reported MDR in poultry, including a 100% MDR in nine articles and a 92.7% (95% CI: 91.2-94%) combined percentage of MDR isolates. Twenty-four different AMR genes encoding resistance to beta-lactams ( , , , , , , , and ), colistin ( and ), fluoroquinolones ( and ), tetracyclines (, , and ), sulfonamides ( and ), trimethoprim (), aminoglycosides (), streptomycin (), gentamicin (), erythromycin (), and chloramphenicol ( and ) were detected in isolates. The presence of MDR and their corresponding resistance genes in poultry and poultry environments is an alarming issue for all health communities in Bangladesh. We suggest a regular antimicrobial surveillance program with a strong One Health approach to lessen the hazardous effects of AMR in poultry industries in Bangladesh.
抗微生物药物耐药性（AMR）是孟加拉国与许多其他发展中国家一样面临的重大公共卫生问题，这些国家的数据显示耐药趋势有限。此外，多药耐药（MDR）的存在对家禽业产生了不祥的影响。因此，本系统评价遵循《系统评价和荟萃分析的首选报告项目》（PRISMA）指南，旨在调查 2010 年至 2021 年间从孟加拉国家禽和家禽环境中分离出的 中的 AMR 情况。根据 PRISMA 指南，共选择了 17 篇已发表的科学文章进行本系统评价。本综述显示，孟加拉国 64 个区中的 18 个区报告了家禽中的 ，其流行率较高（综合流行率：69.3%，95%置信区间，CI：67.3-71%）。此外，流行率范围为 24.3%至 100%。本综述发现， 对 14 种抗菌药物类别和 45 种不同的抗菌药物表现出耐药性，包括最后一线（储备组）抗生素和禁止在农业动物中治疗感染的抗菌类别。 对青霉素和β-内酰胺酶抑制剂（20.2%-100%）、头孢菌素（1.9%-100%）、氟喹诺酮类（5.98%-100%）、氨基糖苷类（6%-100%）、四环素类（17.7%-100%）、碳青霉烯类（13.6%-72.7%）、大环内酯类（11.8%-100%）、多粘菌素类（7.9%-100%）、酚类（20%-97.2%）、磺胺类（44.7%-100%）、头孢菌素类（21.4%-48.8%）、硝基呋喃类（21.4%-63.2%）、单酰胺类（1.2%）和甘氨酰环素类（2.3%）的耐药性在过去几十年中在孟加拉国被记录下来。此外，有 14 篇文章报告了家禽中的 MDR ，其中 9 篇文章的 MDR 率为 100%，95%置信区间（91.2%-94%）的 MDR 分离株综合百分比为 92.7%。24 种不同的 AMR 基因被检测到，这些基因编码对β-内酰胺类（, , , , , , ,和 ）、黏菌素（ 和 ）、氟喹诺酮类（ 和 ）、四环素类（,, 和 ）、磺胺类（ 和 ）、甲氧苄啶（）、氨基糖苷类（）、链霉素（）、庆大霉素（）、红霉素（）和氯霉素（ 和 ）的耐药性。在禽肉和禽肉环境中发现的 MDR 及其相应的耐药基因对孟加拉国所有卫生界都是一个令人震惊的问题。我们建议定期进行抗微生物药物监测计划，并采取强有力的“同一健康”方法，以减轻 AMR 在孟加拉国家禽业中的危险影响。
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