Mir Seyed Mostafa, Aliarab Azadeh, Goodarzi Golnaz, Shirzad Moein, Jafari Seyyed Mehdi, Qujeq Durdi, Samavarchi Tehrani Sadra, Asadi Jahanbakhsh
Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran.
Cell Biochem Funct. 2022 Jan;40(1):4-16. doi: 10.1002/cbf.3672. Epub 2021 Oct 21.
DNA repair is an important pathway for the protection of DNA molecules from destruction. DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation, alkylating agents, depurination and depyrimidination; in this regard, DNA repair pathways can neutralize the negative effects of these factors. Melatonin is a hormone secreted from the pineal gland with an antioxidant effect by binding to oxidative factors. In addition, the effect of melatonin on DNA repair pathways has been proven by the literature. DNA repair is carried out by several mechanisms, of which homologous recombination repair (HRR) and non-homologous end-joining (NHEJ) are of great importance. Because of the importance of DNA repair in DNA integrity and the anticancer effect of this pathway, we presented the effect of melatonin on DNA repair factors regarding previous studies conducted in this area.
DNA修复是保护DNA分子免受破坏的重要途径。DNA损伤可由氧化反应性氮或氧物种、刺激、烷化剂、脱嘌呤和脱嘧啶作用产生；在这方面，DNA修复途径可中和这些因素的负面影响。褪黑素是一种从松果体分泌的激素，通过与氧化因子结合发挥抗氧化作用。此外，褪黑素对DNA修复途径的影响已被文献证实。DNA修复通过多种机制进行，其中同源重组修复（HRR）和非同源末端连接（NHEJ）非常重要。由于DNA修复在DNA完整性方面的重要性以及该途径的抗癌作用，我们根据该领域以前进行的研究介绍了褪黑素对DNA修复因子的影响。
