Hamarat Mustafa Bilal, Ozkent Mehmet Serkan, Yilmaz Burak, Aksanyar Salih Yahya, Karabacak Kadir
Department of Urology, University of Health Sciences University, Konya City Hospital, Konya, Turkey.
Department of Embryology, University of Health Sciences, Konya City Hospital, Konya, Turkey.
Can Urol Assoc J. 2022 Mar;16(3):E173-E177. doi: 10.5489/cuaj.7292.
In this study, we aimed to assess the effect of SARS-CoV-2 infection on semen parameters in one group of patients before and after infection.
Patients were screened if they had a semen analysis performed between October 1, 2019, and December 1, 2020, in the assisted reproduction unit and later had positive polymerase chain reaction (PCR) test for SARS-CoV-2 infection. The patients' semen parameters were recorded before and after SARS-CoV-2 infection, along with degrees of SARS-CoV-2 infection, dates of SARS-CoV-2 infection, durations between the treatment for SARS-CoV-2 infection and the second semen analysis, time of symptom onset, duration of their symptoms, ages, comorbidities, and any medications patients were taking.
Forty-one patients were included in the study. The mean age of the patients was 31.29±5.95 years. The mean duration from first semen analysis to the PCR test was 7.74±3.03 months. The mean duration between the PCR test and later semen analysis was 2.35±1.35 months. The median sperm concentration for the patients before and after SARS-CoV-2 infection were 24 mil/ml and 13 mil/ml, respectively (p<0.001). The normal morphology percentage before infection was 3.16±0.92, while it was 2.44±1.04 after infection (p=0.011). In 26 patients, the period from the time of infection to the second semen analysis was over 70 days, while this period was less than 70 days in the other 15 patients. In both patient groups, a significant decrease was detected in the sperm concentrations and total sperm count.
In the semen samples we assessed, we observed a significant decrease in the mean sperm concentration, total sperm count, and mean percentage of samples with normal morphology after SARS-CoV-2 infection.
在本研究中，我们旨在评估一组患者感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）前后，该病毒感染对精液参数的影响。
筛选2019年10月1日至2020年12月1日期间在辅助生殖科进行精液分析，随后严重急性呼吸综合征冠状病毒2感染核酸检测呈阳性的患者。记录患者感染SARS-CoV-2前后的精液参数，以及SARS-CoV-2感染程度、感染日期、SARS-CoV-2感染治疗与第二次精液分析之间的间隔时间、症状出现时间、症状持续时间、年龄、合并症以及患者正在服用的任何药物。
41名患者纳入研究。患者的平均年龄为31.29±5.95岁。从首次精液分析到核酸检测的平均时间为7.74±3.03个月。核酸检测与随后精液分析之间的平均时间为2.35±1.35个月。SARS-CoV-2感染前后患者的精子浓度中位数分别为2400万/毫升和1300万/毫升（p<0.001）。感染前正常形态百分比为3.16±0.92，感染后为2.44±1.04（p=0.011）。26名患者从感染到第二次精液分析的时间超过70天，而其他15名患者此时间段少于70天。在两组患者中，均检测到精子浓度和精子总数显著下降。
在我们评估的精液样本中，我们观察到SARS-CoV-2感染后平均精子浓度、精子总数以及正常形态样本的平均百分比显著下降。
