Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, Jordan.
Department of Biological Sciences, Al al-Bayt University, Mafraq, Jordan.
Andrologia. 2020 Oct;52(9):e13791. doi: 10.1111/and.13791. Epub 2020 Aug 13.
Male infertility is linked to some viral infections including human papillomavirus (HPV), herpes simplex viruses (HSV) and human immunodeficiency viruses (HIVs). Almost nothing is known about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effect on fertility. The possible risk factors of coronavirus disease 2019 (COVID-19) infection on fertility comes from the abundance of angiotensin-Converting Enzyme-2 (ACE2), receptor entry of the virus, on testes, a reduction in important sex hormone ratios and COVID-19-associated fever. Recent studies have shown a gender difference for COVID-19 rates and comorbidity. In this review, we will discuss the potential effect of COVID-19 on male fertility and talk about what needs to be done by the scientific community to tackle our limited understanding of the disease. On the other side, we will focus on what is known so far about the risk of COVID-19 on pregnancy, neonatal health and the vertical transfer of the virus between mothers and their neonates. Finally, because reproduction is a human right and infertility is considered a health disease, we will discuss how assisted reproductive clinics can cope with the pandemic and what guidelines they should follow to minimise the risk of viral transmission.
男性不育与某些病毒感染有关,包括人乳头瘤病毒(HPV)、单纯疱疹病毒(HSV)和人类免疫缺陷病毒(HIVs)。几乎没有人知道严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)对生育能力的影响。新型冠状病毒病 2019(COVID-19)感染对生育能力的可能危险因素来自于病毒受体进入睾丸的大量血管紧张素转换酶-2(ACE2),重要性激素比例的降低以及 COVID-19 相关的发热。最近的研究表明 COVID-19 的发病率和合并症存在性别差异。在这篇综述中,我们将讨论 COVID-19 对男性生育能力的潜在影响,并讨论科学界需要做些什么来解决我们对这种疾病的有限认识。另一方面,我们将重点介绍迄今为止关于 COVID-19 对妊娠、新生儿健康以及病毒在母亲及其新生儿之间垂直传播的风险的了解。最后,因为生殖是一项人权,不育被认为是一种健康疾病,我们将讨论辅助生殖诊所如何应对这一大流行病,以及他们应该遵循哪些指导方针来将病毒传播的风险降到最低。