Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, 160062 Punjab, India.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, 160062 Punjab, India.
Int J Pharm. 2021 Dec 15;610:121203. doi: 10.1016/j.ijpharm.2021.121203. Epub 2021 Oct 19.
The deep eutectic system (DES) is a relatively new concept in the field of drug delivery science. DES is a class of eutectic mixtures comprised of two or more components, with a eutectic point far below than the melting temperature of the pure components. The strong hydrogen bonding interactions between DES constituents are responsible for significant lowering of melting point in DES. A significant number of molecules cannot reach from drug discovery phase to drug development phase because of poor biopharmaceutical attributes, such as solubility and permeability. DES can be a novel alternative to overcome these issues. In last few years DESs have been widely used in different pharmaceutical and chemical processes. However, comprehensive information regarding their drug delivery potential is not available. This review deals with fundamental aspects such as types, preparation, thermodynamics, toxicity, biodegradability and their applications in the field of drug delivery. Current challenges, future prospects and translational aspects of DES as drug delivery system have also been discussed.
深共熔体系（DES）是药物输送科学领域的一个相对较新的概念。DES 是由两种或多种成分组成的共晶混合物，共晶点远低于纯成分的熔点。DES 成分之间的强氢键相互作用导致 DES 的熔点显著降低。由于生物制药特性（如溶解度和渗透性）差，大量分子无法从药物发现阶段进入药物开发阶段。DES 可以作为克服这些问题的一种新方法。在过去的几年中，DES 已广泛应用于不同的制药和化学过程中。然而，关于它们在药物输送中的潜在应用的综合信息尚不可用。本文综述了 DES 的基本方面，如类型、制备、热力学、毒性、生物降解性及其在药物输送领域的应用。还讨论了 DES 作为药物输送系统的当前挑战、未来前景和转化方面。
