Akinlosotu B A, Diehl J R, Gimenez T
Prostaglandins. 1986 Aug;32(2):291-9. doi: 10.1016/0090-6980(86)90132-2.
Twelve crossbred gilts, 8 to 9 months of age, were used to study the effects of prostaglandin E2 (PGE2) on luteal function during the estrous cycle. Intrauterine and jugular vein catheters were surgically placed before day 7 of the treatment estrous cycle and gilts were randomly assigned to 1 of 3 treatment groups. Groups I and II received constant intrauterine infusion of vehicle (6.0 ml/24 hr) or PGE2 (2400 micrograms/day; 6.0 ml/24 hr) respectively; while group III was given intrauterine infusions of 400 micrograms PGE2 every 4 hr. All infusions were initiated on day 7 and continued until estrus or through day 23. Jugular blood samples were collected twice daily from days 7 to 30 for progesterone analysis. Intrauterine infusion of PGE2 at the dose and frequencies given in this study delayed the decline in jugular plasma progesterone and resulted in prolongation of the estrous cycle length. The results of this study have shown that PGE2 at the dosage and frequency of administration used was capable of extending corpus luteum function.
选用12头8至9月龄的杂交后备母猪，研究前列腺素E2（PGE2）在发情周期中对黄体功能的影响。在治疗发情周期的第7天之前，通过手术在子宫内和颈静脉放置导管，将母猪随机分为3个治疗组中的1组。第一组和第二组分别持续子宫内输注赋形剂（6.0毫升/24小时）或PGE2（2400微克/天；6.0毫升/24小时）；而第三组每4小时进行一次400微克PGE2的子宫内输注。所有输注均在第7天开始，持续至发情或直至第23天。从第7天到第30天每天采集两次颈静脉血样进行孕酮分析。本研究中以给定的剂量和频率进行子宫内输注PGE2可延迟颈静脉血浆孕酮的下降，并导致发情周期长度延长。本研究结果表明，所用剂量和给药频率的PGE2能够延长黄体功能。
