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具有 ROS 清除活性的空心 CeO 减轻小鼠结肠炎。

Hollow CeO with ROS-Scavenging Activity to Alleviate Colitis in Mice.

机构信息

Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People's Republic of China.

Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

出版信息

Int J Nanomedicine. 2021 Oct 8;16:6889-6904. doi: 10.2147/IJN.S317261. eCollection 2021.

DOI:10.2147/IJN.S317261
PMID:34675513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8521620/
Abstract

INTRODUCTION

Excessive production of reactive oxygen species (ROS) to induce high oxidative stress is one of the main causes of colitis; thus, it has been regarded as a therapeutic target for colitis treatment. And the nanomaterial-based therapeutic strategies are effective against colitis. However, the previous elaborately designed materials exhibit limited application due to the uncertain biocompatibility and complicated manufacturing processes.

METHODS

In this study, the highly monodisperse hollow CeO nanoparticles (H-CeO) with uniform morphology were obtained by in situ growing CeO on solid silica nanoparticles and subsequently removing the silica core. The H-CeO was further modified with PEG, which owned excellent biological stability and biocompatibility. The experimental model of colitis induced by dextran sulfate sodium (DSS) was used to investigate the anti-inflammatory effect of H-CeO-PEG.

RESULTS

The H-CeO-PEG showed good ROS scavenging efficacy and decreased the levels of proinflammatory cytokines (IL-6, IL-1β, IL-18, and TNF-α) in DSS-induced colitis mice. Furthermore, H-CeO-PEG inhibited the activation of the MAPK signalling pathway to alleviate colitis.

CONCLUSION

This study reveals the therapeutic effects of CeO-based nanomedicine toward colitis and elucidates the specific signalling pathway involved, which provides potential alternative therapeutic options for patients with inflammation tissue.

摘要

简介

过量产生的活性氧（ROS）会引发高氧化应激，这是结肠炎的主要原因之一；因此，它已被视为结肠炎治疗的一个治疗靶点。基于纳米材料的治疗策略对结肠炎有效。然而，由于不确定的生物相容性和复杂的制造工艺，以前精心设计的材料的应用受到限制。

方法

在这项研究中，通过在固体二氧化硅纳米颗粒上原位生长 CeO，然后去除二氧化硅核，获得了形态均匀的高单分散空心 CeO 纳米颗粒（H-CeO）。进一步用 PEG 对 H-CeO 进行修饰，具有优异的生物稳定性和生物相容性。使用葡聚糖硫酸钠（DSS）诱导的结肠炎实验模型来研究 H-CeO-PEG 的抗炎作用。

结果

H-CeO-PEG 表现出良好的 ROS 清除效果，并降低了 DSS 诱导的结肠炎小鼠中促炎细胞因子（IL-6、IL-1β、IL-18 和 TNF-α）的水平。此外，H-CeO-PEG 抑制了 MAPK 信号通路的激活，从而减轻了结肠炎。

结论

本研究揭示了基于 CeO 的纳米医学在结肠炎治疗中的疗效，并阐明了所涉及的特定信号通路，为炎症组织患者提供了潜在的替代治疗选择。

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