C反应蛋白/血小板比值在新生儿败血症中的临床价值：一项横断面研究
Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study.
作者信息
Li Xiaojuan, Li Tiewei, Wang Jingjing, Feng Yichuan, Ren Chong, Xu Zhe, Yang Junmei, Zhang Qian, An Caiyan
机构信息
Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, People's Republic of China.
Department of Neonatology, Ordos Central Hospital, Ordos, 01700, People's Republic of China.
出版信息
J Inflamm Res. 2021 Oct 6;14:5123-5129. doi: 10.2147/JIR.S334642. eCollection 2021.
PURPOSE
C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis.
METHODS
A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/PLT (10 cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis.
RESULTS
Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008-1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000-1.003, P = 0.007). ROC curve revealed showed that CPR had a well-discriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65-0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65-0.72, P < 0.001).
CONCLUSION
The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.
目的
C反应蛋白（CRP）水平和血小板（PLT）计数已被证明是新生儿败血症的独立危险因素。然而，目前尚无关于CRP与血小板比值（CPR）和新生儿败血症之间关联的数据。
方法
本研究共纳入1048例疑似败血症的新生儿。收集完整的临床和实验室数据。CPR计算公式为CRP（mg/L）/PLT（10⁹细胞/L）。进行多因素逻辑回归分析以确定新生儿败血症的潜在独立危险因素。采用受试者工作特征（ROC）曲线分析评估CPR对新生儿败血症的预测准确性。
结果
败血症新生儿的CPR较高。在感染组、轻度败血症组和重度败血症组中，CPR也呈逐渐升高趋势。多因素分析显示，CPR是新生儿败血症存在的显著独立预测因素（比值比[OR]，1.015；95%置信区间[CI]，1.008 - 1.022，P < 0.001）以及重度败血症的独立预测因素（OR，1.002；95%CI，1.000 - 1.003，P = 0.007）。ROC曲线显示，CPR在预测败血症（曲线下面积[AUC]，0.68；95%CI，0.65 - 0.72，P < 0.001）和重度败血症（AUC，0.68；95%CI，0.65 - 0.72，P < 0.001）方面具有良好的辨别能力。
结论
本研究表明，较高的CPR是新生儿败血症存在及严重程度的独立预测因素。
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