Department of Clinical Microbiology Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 150, Ximen Street, Taizhou, 317000, Zhejiang, China.
BMC Infect Dis. 2022 Jul 21;22(1):636. doi: 10.1186/s12879-022-07613-x.
The purpose of the current study was to evaluate the association between C-reactive protein-to-platelet ratio (CPR), neutrophil-to-lymphocyte*platelet ratio (NLPR) and fibrinogen-to-platelet ratio (FPR) and the prognoses of pyogenic liver abscess (PLA) patients.
A cohort of 372 patients with confirmed PLA were enrolled in this retrospective study between 2015 and 2021. Laboratory data were collected on admission within 24 h. The demographic characteristics and clinical features were recorded. Risk factors for outcomes of PLA patients were determined via multivariate logistic regression analyses, and optimal cut-off values were estimated by using the receiver operating characteristic (ROC) curve analysis.
Out of 372 patients, 57.8% were men, 80 (21.5%) developed sepsis, and 33 (8.9%) developed septic shock. The levels of CPR, NLPR and FPR were significantly increased in the development of sepsis, and prolonged hospital stays in PLA patients. The multivariate logistic regression analysis indicated that the CPR (OR: 2.262, 95% CI: 1.586-3.226, p < 0.001), NLPR (OR: 1.118, 95% CI: 1.070-1.167, p < 0.001) and FPR (OR: 1.197, 95% CI: 1.079-1.329, p = 0.001) were independent risks of PLA patients with sepsis, and NLPR (OR: 1.019, 95% CI: 1.004-1.046, p = 0.019) was shown to be an independent predictor of prolonged hospital stays. The ROC curve results showed that the three biomarkers had different predictive values, and CPR proved to work best, with a ROC value of 0.851 (95% CI: 0.807-0.896, p < 0.001) for sepsis.
Higher levels of CPR, NLPR and FPR were associated with a higher risk of poor outcomes. Moreover, a high CPR level performed best when predicting the clinical outcome in PLA patients.
本研究旨在评估 C 反应蛋白与血小板比值（CPR）、中性粒细胞与淋巴细胞*血小板比值（NLPR）和纤维蛋白原与血小板比值（FPR）与化脓性肝脓肿（PLA）患者预后的相关性。
本回顾性研究纳入了 2015 年至 2021 年间确诊为 PLA 的 372 例患者。在入院 24 小时内采集实验室数据。记录人口统计学特征和临床特征。采用多变量逻辑回归分析确定 PLA 患者结局的危险因素，并通过接受者操作特征（ROC）曲线分析估计最佳截断值。
372 例患者中，57.8%为男性，80 例（21.5%）发生脓毒症，33 例（8.9%）发生感染性休克。CPR、NLPR 和 FPR 水平在脓毒症的发生和 PLA 患者住院时间延长中显著升高。多变量逻辑回归分析表明，CPR（比值比：2.262，95%置信区间：1.586-3.226，p<0.001）、NLPR（比值比：1.118，95%置信区间：1.070-1.167，p<0.001）和 FPR（比值比：1.197，95%置信区间：1.079-1.329，p=0.001）是 PLA 患者发生脓毒症的独立危险因素，NLPR（比值比：1.019，95%置信区间：1.004-1.046，p=0.019）是住院时间延长的独立预测因子。ROC 曲线结果表明，三种生物标志物具有不同的预测价值，CPR 的预测效果最佳，ROC 值为 0.851（95%置信区间：0.807-0.896，p<0.001），用于预测 PLA 患者的临床结局。
较高水平的 CPR、NLPR 和 FPR 与不良预后风险增加相关。此外，CPR 水平升高对预测 PLA 患者的临床结局效果最佳。
