Liu Guoxiang, Yang Lina, Chen Guang, Xu Fenghua, Yang Fanghao, Yu Huaxin, Li Lingne, Dong Xiaolei, Han Jingjing, Cao Can, Qi Jingyu, Su Junzhe, Xu Xiaohui, Li Xiaoxia, Li Bing
Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, China.
Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Front Pharmacol. 2021 Oct 4;12:735446. doi: 10.3389/fphar.2021.735446. eCollection 2021.
In recent years, with the development of nanomaterials, the research of drug delivery systems has become a new field of cancer therapy. Compared with conventional antitumor drugs, drug delivery systems such as drug nanoparticles (NPs) are expected to have more advantages in antineoplastic effects, including easy preparation, high efficiency, low toxicity, especially active tumor-targeting ability. Drug delivery systems are usually composed of delivery carriers, antitumor drugs, and even target molecules. At present, there are few comprehensive reports on a summary of drug delivery systems applied for tumor therapy. This review introduces the preparation, characteristics, and applications of several common delivery carriers and expounds the antitumor mechanism of different antitumor drugs in delivery carriers in detail which provides a more theoretical basis for clinical application of personalized cancer nanomedicine in the future.
近年来，随着纳米材料的发展，药物递送系统的研究已成为癌症治疗的一个新领域。与传统抗肿瘤药物相比，药物纳米颗粒（NPs）等药物递送系统有望在抗肿瘤作用方面具有更多优势，包括易于制备、高效、低毒，尤其是具有主动肿瘤靶向能力。药物递送系统通常由递送载体、抗肿瘤药物甚至靶向分子组成。目前，关于应用于肿瘤治疗的药物递送系统综述的全面报道较少。本文综述介绍了几种常见递送载体的制备、特点及应用，并详细阐述了不同抗肿瘤药物在递送载体中的抗肿瘤机制，为未来个性化癌症纳米医学的临床应用提供了更多理论依据。
