Department of Medicine (Geriatric Medicine), University College Cork, Wilton, T12 DC4A, Cork, Ireland.
Department of Geriatric Medicine, Cork University Hospital, Wilton, Cork, Ireland.
Eur Geriatr Med. 2022 Jun;13(3):579-583. doi: 10.1007/s41999-021-00573-6. Epub 2021 Oct 21.
To assess medication-related quality-of-life (MRQoL) in multi-morbid older adults with polypharmacy and correlations with medications, frailty and health-related QoL.
With a cross sectional study of multi-morbid geriatric medicine outpatients, we assessed MRQoL (MRQol-LSv1), frailty status, potentially inappropriate medications, Medication Adherence Rating Scale (MARS), health-related-QoL (Short-Form 12, SF12) and medication burden (Living with Medicines Questionnaire, LMQv2).
One-in-four (n = 59) of 234 outpatient attendees met inclusion criteria. Almost half (n = 106, 45%) were excluded due to cognition (MMSE < 26). Included participants (n = 27, mean age 80.2 years) experienced a median of 11 (IQR 9-13.5) co-morbidities and were prescribed a median of 10 (IQR 8-12.25) medications. Overall, MRQoL-LS.v.1 scores were low, suggesting good medication-related quality of life (median MRQoL-LS.v.1 score of 14, IQR 14-22). Correlations between MRQoL, number of daily medications, co-morbidity burden, LMQv2 score, SF12 scores and number of PIMs were non-significant.
MRQoL-LSv.1 is unsuitable for most patients attending geriatric ambulatory services.
评估患有多种疾病且服用多种药物的老年患者的药物相关生活质量（MRQoL）与药物、虚弱和健康相关生活质量的相关性。
采用多病态老年医学门诊患者的横断面研究，评估 MRQoL（MRQol-LSv1）、虚弱状况、潜在不适当药物、药物依从性评定量表（MARS）、健康相关生活质量（SF12）和药物负担（用药生活质量问卷，LMQv2）。
234 名门诊患者中，有 1/4（n=59）符合纳入标准。由于认知功能（MMSE<26），近一半（n=106，45%）患者被排除在外。纳入的患者（n=27，平均年龄 80.2 岁）患有 11 种（IQR 9-13.5）共病，平均服用 10 种（IQR 8-12.25）药物。总体而言，MRQoL-LS.v.1 评分较低，表明药物相关生活质量良好（MRQoL-LS.v.1 评分中位数为 14，IQR 14-22）。MRQoL 与每日用药数量、共病负担、LMQv2 评分、SF12 评分和 PIM 数量之间的相关性均无统计学意义。
MRQoL-LSv.1 不适用于大多数接受老年门诊服务的患者。
