Department of Clinical Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan; Department of Clinical Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey.
Department of Biostatistics, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
Med Gas Res. 2022 Apr-Jun;12(2):51-54. doi: 10.4103/2045-9912.325992.
Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.
新型冠状病毒病 2019（COVID-19）引发常规血液检测的重要变化。在这项回顾性病例对照研究中，我们分析了 2020 年 3 月 10 日至 11 月 30 日期间 3969 例 COVID-19 患者（非重症监护病房（非 ICU）组 3746 例和 ICU 组 223 例）的生化、血液学和炎症生物标志物，并按春、夏、秋三个季节进行分组。在非 ICU 组中，与其他两个季节相比，秋季淋巴细胞与单核细胞比值较低，中性粒细胞与淋巴细胞比值较高。此外，春季单核细胞和血小板高于秋季；而嗜酸性粒细胞、红细胞压积、血红蛋白、淋巴细胞和红细胞从春季到秋季逐渐减少。在非 ICU 组中，丙氨酸氨基转移酶和γ-谷氨酰转移酶从春季到秋季逐渐升高，而白蛋白、碱性磷酸酶、钙、总胆红素和总蛋白逐渐降低。此外，秋季 C-反应蛋白高于其他季节，秋季红细胞沉降率高于夏季。COVID-19 常规血液生物标志物的变化从疾病出现到现在一直在变化。此外，血液生物标志物的及时变化大多更为负面，表明疾病进展严重。该研究于 2021 年 6 月 21 日获得埃尔津詹比纳利·耶尔德勒姆大学非介入性临床试验伦理委员会的批准（批准号：86041）。
