Fukuzawa Satoshi, Yamagata Kenji, Okubo-Sato Makiko, Terada Kazuhiro, Uchida Fumihiko, Ishibashi-Kanno Naomi, Bukawa Hiroki
Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan.
Dent J (Basel). 2021 Oct 14;9(10):119. doi: 10.3390/dj9100119.
Various treatments for oral vascular malformation (VM) have been reported. Polidocanol and absolute ethanol have also been reported for sclerotherapy. However, there are still few reports on the therapeutic effect and dosage of polidocanol sclerotherapy. Therefore, we examined its therapeutic effects on oral VM. There were 17 sites of VMs, with nine patients diagnosed with oral VM at the Department of Dental and Oral Surgery, Tsukuba University Hospital. The medical records were retrospectively investigated to determine the site, hemangioma volume, polidocanol injection volume, and therapeutic effect. The volume of hemangiomas was calculated using magnetic resonance images. Based on the site, oral VMs were observed in the tongue, buccal mucosa, lips, and oral floor in eight, three, five, and one patients, respectively. The average size of the site was 3071 mm. The average injection dose of polidocanol at one site was 2.86 mL, the average number of administrations was 1.6, and the response rate was 88.2%. No adverse events were observed. The median numerical rating scale scores were 2/10 (0-6/10) and 0/10 (0-1/10) the day after surgery and 1 week after surgery, respectively. Univariate regression analysis of the total dose in successful cases provided the following formula: 1.3 + 0.00025 × volume (mm) (mg). Polidocanol sclerotherapy is an effective treatment method for oral VM.
已有多种治疗口腔血管畸形（VM）的方法被报道。聚多卡醇和无水乙醇也被用于硬化治疗。然而，关于聚多卡醇硬化治疗的疗效和剂量的报道仍然很少。因此，我们研究了其对口腔VM的治疗效果。共有17个VM部位，9例患者在筑波大学医院口腔颌面外科被诊断为口腔VM。对病历进行回顾性研究，以确定病变部位、血管瘤体积、聚多卡醇注射量和治疗效果。血管瘤体积通过磁共振成像计算。根据病变部位，分别在8例、3例、5例和1例患者的舌、颊黏膜、唇和口底观察到口腔VM。病变部位的平均大小为3071立方毫米。一个部位聚多卡醇的平均注射剂量为2.86毫升，平均给药次数为1.6次，有效率为88.2%。未观察到不良事件。术后第1天和术后1周的数字评定量表评分中位数分别为2/10（0 - 6/10）和0/10（0 - 1/10）。对成功病例的总剂量进行单因素回归分析得到以下公式：1.3 + 0.00025×体积（立方毫米）（毫克）。聚多卡醇硬化治疗是一种治疗口腔VM的有效方法。
