同步双侧乳腺癌中衰老和凋亡生物标志物的表达：一例报告
Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report.
作者信息
Saleh Tareq, El-Sadoni Mohammed, Alhesa Ahmad, Awad Heyam, Jaradat Mahmoud, Al-Hazaimeh Mohammad, Dawoud Rand, Mryyian Amel, Azab Bilal
机构信息
Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan.
出版信息
Curr Oncol. 2021 Sep 30;28(5):3836-3845. doi: 10.3390/curroncol28050327.
BACKGROUND
Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined.
METHODS
In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis.
RESULTS
Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates.
CONCLUSIONS
Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.
背景
同步双侧乳腺癌（SBBC）提供了一种特殊情况，即两个独立的乳腺肿瘤在统一的药代动力学环境中接受癌症药物治疗。衰老和凋亡都是对治疗的既定反应；然而，它们对治疗总体结果的贡献可能各不相同，尚待确定。
方法
在本报告中，我们描述了两例接受标准抗癌治疗的SBBC病例的临床病理情况，并评估了它们衰老和凋亡的几个分子标志物的表达谱。
结果
我们的分析发现，尽管对新辅助化疗的病理反应和当前生存率相当，但同步肿瘤的衰老和凋亡相关生物标志物的表达谱各不相同。
结论
我们的结果突出了乳腺肿瘤中衰老和凋亡相关标志物的可变表达（尽管有共同的体细胞遗传背景），并呼吁对体内乳腺癌组织中的衰老和凋亡及其对病理反应和总体生存的贡献进行大规模评估。
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