新型冠状病毒肺炎感染与神经病理学特征
COVID-19 Infection and Neuropathological Features.
作者信息
Freire-de-Lima Leonardo, Scovino Aline Miranda, Marques da Fonseca Leonardo, Barreto Menezes Camilla Cristie, Santos Carlos Antonio do Nascimento, Freire de Lima Marco Edilson, Decote-Ricardo Debora, Freire-de-Lima Matheus, da Costa Kelli Monteiro, Dos Reis Jhenifer Santos, Rodrigues da Costa Santos Marcos André, Freire-de-Lima Celio Geraldo, Morrot Alexandre
机构信息
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil.
出版信息
Medicines (Basel). 2021 Oct 11;8(10):59. doi: 10.3390/medicines8100059.
The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.
与新型冠状病毒肺炎（COVID-19）感染相关的病理学正在逐步被揭示。最近的尸检评估显示存在急性气道炎症以及弥漫性肺泡损伤，这与由严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）感染所引发的严重急性呼吸综合征相似。尽管最近的论文强调了一些与COVID-19感染相关的神经病理学，但在公共卫生领域这个极其重要的话题上，人们所知甚少。在此，我们讨论在感染过程中，与COVID-19相关的神经炎症如何可能由病毒直接侵袭神经和/或细胞因子释放所触发。
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