Jin Taiyue, Park Eun Young, Kim Byungmi, Oh Jin-Kyoung
Division of Cancer Prevention, National Cancer Control Institute, National Cancer Center, Goyang-si 10408, Gyeonggi-do, Korea.
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si 10408, Gyeonggi-do, Korea.
Toxics. 2021 Sep 29;9(10):242. doi: 10.3390/toxics9100242.
There is limited evidence on the association between blood mercury (Hg) concentration and the risk of borderline dyslipidemia in adolescents. Here, we investigated the association between blood Hg concentration and the prevalence of borderline dyslipidemia among Korean adolescents. A total of 1559 participants (806 boys and 753 girls) aged 10-18 years who cross-sectionally enrolled in the Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2013 and 2016 were included in this study. Hg concentrations (µg/L) in whole blood samples were measured. The geometric mean (GM) of the blood Hg concentration was 1.88 µg/L. It showed a 63% higher prevalence of borderline hypercholesterolemia (total cholesterol (TC) 170-199 mg/dL) per unit of natural log-transformed blood Hg concentration in boys (95% CI = 1.10-2.41), but not in girls. When a categorical model was applied, the positive association with the prevalence of borderline hypercholesterolemia was also persistant in boys (OR (95% CI) for 2nd and 3rd tertiles (Hg concentration 1.532-11.761 µg/L) vs. 1st tertile (Hg concentration 0.192-1.531 µg/L): 1.92 (1.19-3.10)), but not in girls. This finding suggests that blood Hg concentration might result in a higher prevalence of borderline hypercholesterolemia among adolescents and more stringent public health actions should be taken for the reduction of Hg exposure to prevent dyslipidemia from early-childhood, despite the need of further study to evaluate a causal relationship between blood Hg concentration and the risk of dyslipidemia.
关于青少年血液汞（Hg）浓度与临界血脂异常风险之间的关联，证据有限。在此，我们调查了韩国青少年血液Hg浓度与临界血脂异常患病率之间的关联。本研究纳入了2010 - 2013年和2016年横断面参加韩国国家健康与营养检查调查（KNHANES）的1559名10 - 18岁参与者（806名男孩和753名女孩）。测量了全血样本中的Hg浓度（μg/L）。血液Hg浓度的几何均值（GM）为1.88μg/L。每单位自然对数转换后的血液Hg浓度，男孩临界高胆固醇血症（总胆固醇（TC）170 - 199mg/dL）的患病率高63%（95%CI = 1.10 - 2.41），但女孩中未出现此情况。当应用分类模型时，男孩中临界高胆固醇血症患病率的正相关关系也持续存在（第二和第三三分位数（Hg浓度1.532 - 11.761μg/L）与第一三分位数（Hg浓度0.192 - 1.531μg/L）相比的OR（95%CI）：1.92（1.19 - 3.10）），但女孩中不存在。这一发现表明，血液Hg浓度可能导致青少年临界高胆固醇血症患病率更高，尽管需要进一步研究来评估血液Hg浓度与血脂异常风险之间的因果关系，但仍应采取更严格的公共卫生行动以减少Hg暴露，从幼儿期预防血脂异常。
