Riaz Rajoka Muhammad Shahid, Thirumdas Rohit, Mehwish Hafiza Mahreen, Umair Muhammad, Khurshid Mohsin, Hayat Hafiz Fakhar, Phimolsiripol Yuthana, Pallarés Noelia, Martí-Quijal Francisco J, Barba Francisco J
Health Science Center, School of Pharmaceutical Science, Shenzhen University, Shenzhen 518060, China.
Food and Feed Immunology Group, Laboratory of Animal Food Function, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan.
Antioxidants (Basel). 2021 Sep 30;10(10):1563. doi: 10.3390/antiox10101563.
Dietary components have an important role on the structure and function of host gut microbial communities. Even though, various dietary components, such as carbohydrates, fats, proteins, fibers, and vitamins, have been studied in depth for their effect on gut microbiomes, little attention has been paid regarding the impact of several food antioxidants on the gut microbiome. The long-term exposure to reactive oxygen species (ROS) can cause microbial dysbiosis which leads to numerous intestinal diseases such as microbiota dysbiosis, intestinal injury, colorectal cancers, enteric infections, and inflammatory bowel diseases. Recently, it has been shown that the food derived antioxidant compounds might protect the host from intestinal oxidative stress via modulating the composition of beneficial microbial species in the gut. The present review summarizes the impact of food antioxidants including antioxidant vitamins, dietary polyphenols, carotenoids, and bioactive peptides on the structure as well as function of host gut microbial communities. Several in vitro, animal model, and clinical studies indicates that food antioxidants might modify the host gut microbial communities and their health status. However, still further clarification is needed as to whether changes in certain microbial species caused by food additives may lead to changes in metabolism and immune function.
饮食成分对宿主肠道微生物群落的结构和功能具有重要作用。尽管碳水化合物、脂肪、蛋白质、纤维和维生素等各种饮食成分对肠道微生物群的影响已得到深入研究，但几种食物抗氧化剂对肠道微生物群的影响却很少受到关注。长期暴露于活性氧（ROS）会导致微生物失调，进而引发多种肠道疾病，如微生物群失调、肠道损伤、结直肠癌、肠道感染和炎症性肠病。最近的研究表明，食物来源的抗氧化化合物可能通过调节肠道中有益微生物种类的组成，保护宿主免受肠道氧化应激。本综述总结了食物抗氧化剂，包括抗氧化维生素、膳食多酚、类胡萝卜素和生物活性肽，对宿主肠道微生物群落结构和功能的影响。多项体外、动物模型和临床研究表明，食物抗氧化剂可能会改变宿主肠道微生物群落及其健康状况。然而，食物添加剂引起的某些微生物种类的变化是否会导致代谢和免疫功能的改变，仍需要进一步阐明。
