Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Biomolecules. 2021 Oct 4;11(10):1456. doi: 10.3390/biom11101456.
Non-steroidal anti-inflammatory drugs (NSAIDs) are Food and Drug Administration (FDA) approved antipyretic, anti-inflammatory, and analgesic drugs to mitigate pain, however it is associated with gastrointestinal injury and cardiovascular disease in some individuals. Metabolomics has the potential to understand the interaction of host and the drugs, such as NSAIDs administration. This discipline has been used by many researchers to understand the serious side effects of NSAIDs. We highlighted (1) the potential of metabolomics in understanding the pathogenesis of adverse events due to NSAIDs administration; (2) choice of metabolomics techniques, bio sample handling; (3) review of metabolomics studies in the front of NSAIDs in different biofluids and tissues; (4) pathway analysis of the data presented in the published literature. In our analysis we find tricarboxylic acid cycle (TCA), "glycine serine and threonine metabolism," "alanine, aspartate, and glutamate metabolism," and fatty acid metabolism to be altered by the NSAIDs like ibuprofen, indomethacin, naproxen, aspirin, and celecoxib. In conclusion, metabolomics allows the use of biological samples to identify useful pathways involved in disease progression, and subsequently inform a greater understanding of the disease pathogenesis. A further in-depth investigation of the associated pathways mentioned above holds the potential for drug targets for side effects mitigation.
非甾体抗炎药（NSAIDs）是食品和药物管理局（FDA）批准的解热、抗炎和镇痛药，可减轻疼痛，但在某些个体中与胃肠道损伤和心血管疾病有关。代谢组学有可能了解宿主与药物（如 NSAIDs 给药）的相互作用。许多研究人员都使用这一学科来了解 NSAIDs 的严重副作用。我们重点介绍了（1）代谢组学在理解由于 NSAIDs 给药引起的不良事件发病机制方面的潜力；（2）代谢组学技术、生物样本处理的选择；（3）在不同生物流体和组织中 NSAIDs 前代谢组学研究的综述；（4）对已发表文献中呈现的数据进行途径分析。在我们的分析中，我们发现三羧酸循环（TCA）、“甘氨酸、丝氨酸和苏氨酸代谢”、“丙氨酸、天冬氨酸和谷氨酸代谢”和脂肪酸代谢被 NSAIDs（如布洛芬、吲哚美辛、萘普生、阿司匹林和塞来昔布）改变。总之，代谢组学允许使用生物样本来识别与疾病进展相关的有用途径，从而更好地了解疾病发病机制。对上述相关途径进行更深入的调查有可能为减轻副作用的药物靶点提供信息。
