Binarelli Giulia, Joly Florence, Tron Laure, Lefevre Arbogast Sophie, Lange Marie
Clinical Research Department, Centre François Baclesse, 14000 Caen, France.
ANTICIPE, INSERM, UNICAEN, Normandie University, 14000 Caen, France.
Cancers (Basel). 2021 Oct 14;13(20):5161. doi: 10.3390/cancers13205161.
Cancer-related cognitive impairment (CRCI) occurs frequently in patients living with cancer, with consequences on quality of life. Recently, research on the management of these difficulties has focused on computerized cognitive stimulation and computerized physical activity programs. This systematic review presents the state of knowledge about interventions based on computerized-cognitive stimulation and/or physical activity to reduce CRCI. The review followed the PRISMA guidelines. A search was conducted in PUBMED and Web of Science databases. Risk of bias analysis was conducted using the Rob2 tool and the quality of evidence was conducted following the GRADE approach. A total of 3776 articles were initially identified and 20 of them met the inclusion criteria. Among them, sixteen investigated computerized-cognitive stimulation and four computerized-physical activity. Most of the studies were randomized controlled trials and assessed the efficacy of a home-based intervention on objective cognition in adults with cancer. Overall, cognitive improvement was found in 11/16 computerized-cognitive stimulation studies and 2/4 computerized-physical activity studies. Cognitive stimulation or physical activity improved especially cognitive complaints, memory, and attention. These results suggest the efficacy of both computerized-cognitive stimulation and physical activity. However, we report a high risk of bias for the majority of studies and a low level of quality of evidence. Therefore, further investigations are needed to confirm the efficacy of these interventions and to investigate the possible added benefit on cognition of a combined computerized-cognitive/physical intervention.
癌症相关认知障碍（CRCI）在癌症患者中频繁出现，会对生活质量产生影响。最近，针对这些困难的管理研究主要集中在计算机化认知刺激和计算机化体育活动项目上。本系统综述介绍了基于计算机化认知刺激和/或体育活动以减轻CRCI的干预措施的知识现状。该综述遵循PRISMA指南。在PubMed和科学网数据库中进行了检索。使用Rob2工具进行偏倚风险分析，并按照GRADE方法评估证据质量。最初共识别出3776篇文章，其中20篇符合纳入标准。其中，16项研究调查了计算机化认知刺激，4项研究调查了计算机化体育活动。大多数研究为随机对照试验，评估了家庭干预对成年癌症患者客观认知的疗效。总体而言，在16项计算机化认知刺激研究中有11项发现了认知改善，在4项计算机化体育活动研究中有2项发现了认知改善。认知刺激或体育活动尤其改善了认知主诉、记忆力和注意力。这些结果表明计算机化认知刺激和体育活动均有效。然而，我们报告大多数研究存在较高的偏倚风险且证据质量较低。因此，需要进一步研究以确认这些干预措施的疗效，并研究计算机化认知/体育联合干预对认知可能带来的额外益处。
