Areklett E W, Hagen B I, Stubberud J, Fagereng E, Andersson S, Lindemann K
Department of Oncology, Oslo University Hospital, PB 4953 Nydalen, 0424, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
J Cancer Surviv. 2024 Nov 22. doi: 10.1007/s11764-024-01701-4.
Cognitive impairment (CI) is a common late effect after cancer treatment, for which effective interventions are lacking. Goal management training (GMT) is a validated cognitive training protocol reported to improve cognition, including executive functioning. The purpose of this study was to examine the feasibility and acceptability of digital GMT in cervical cancer survivors (CCS) experiencing CI and compare it to computerized cognitive training (CCT).
Thirty-five CCS with significant subjective CI were randomized in a 1:1 ratio between digital GMT (N = 18) and CCT (N = 17). The primary endpoint was attendance, and participants attending ≥ 80% of the sessions were categorized as completers. Acceptability was evaluated post-intervention using the Client Satisfaction Questionnaire-8 (CSQ-8). Secondary outcomes included self-reported and performance-based cognitive functioning.
The completion rate in both groups was 88%. Participants in both groups reported high levels of satisfaction (CSQ-8; GMT: M = 25.2, SD 3.7, range 18-31, and CCT: M = 24.6, SD 3.1, range 19-30). Exploratory analyses showed improvements in both groups over time in attention and memory as well as self-reported cognitive functioning.
Digital GMT is feasible with a high level of compliance and satisfaction in CCS. Preliminary efficacy data shows promising cognitive improvement over time, and the results are comparable to CCT and warrant further investigation in a larger-scale trial.
If deemed effective in a larger study, digital cognitive training, such as GMT, is a low-cost, low-staff intensive intervention that is easily implemented and available to cancer survivors experiencing CI.
认知障碍（CI）是癌症治疗后常见的晚期效应，目前缺乏有效的干预措施。目标管理训练（GMT）是一种经过验证的认知训练方案，据报道可改善认知，包括执行功能。本研究的目的是检验数字GMT在患有CI的宫颈癌幸存者（CCS）中的可行性和可接受性，并将其与计算机化认知训练（CCT）进行比较。
35名有明显主观CI的CCS按1:1比例随机分为数字GMT组（N = 18）和CCT组（N = 17）。主要终点是出勤率，参加≥80%课程的参与者被归类为完成者。干预后使用客户满意度问卷-8（CSQ-8）评估可接受性。次要结果包括自我报告的和基于表现的认知功能。
两组的完成率均为88%。两组参与者均报告了较高的满意度（CSQ-8；GMT组：M = 25.2，标准差3.7，范围18 - 31；CCT组：M = 24.6，标准差3.1，范围19 - 30）。探索性分析显示，两组随着时间推移在注意力、记忆力以及自我报告的认知功能方面均有改善。
数字GMT在CCS中具有可行性，依从性和满意度较高。初步疗效数据显示随着时间推移认知有显著改善，结果与CCT相当，值得在更大规模试验中进一步研究。
如果在更大规模研究中被证明有效，数字认知训练，如GMT，是一种低成本、低人力需求的干预措施，易于实施，可供患有CI的癌症幸存者使用。
