Sanchez Alberto, Morales Ingrid, Rodriguez-Sabate Clara, Sole-Sabater Miguel, Rodriguez Manuel
Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, 38200 Tenerife, Spain.
Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain.
Biomedicines. 2021 Sep 28;9(10):1341. doi: 10.3390/biomedicines9101341.
At present, there is no efficient treatment to prevent the evolution of Parkinson's disease (PD). PD is generated by the concurrent activity of multiple factors, which is a serious obstacle for the development of etio-pathogenic treatments. Astrocytes may act on most factors involved in PD and the promotion of their neuroprotection activity may be particularly suitable to prevent the onset and progression of this basal ganglia (BG) disorder. The main causes proposed for PD, the ability of astrocytes to control these causes, and the procedures that can be used to promote the neuroprotective action of astrocytes will be commented upon, here.
目前，尚无有效的治疗方法来阻止帕金森病（PD）的进展。PD是由多种因素共同作用产生的，这是病因治疗发展的严重障碍。星形胶质细胞可能作用于PD涉及的大多数因素，促进其神经保护活性可能特别适合预防这种基底神经节（BG）疾病的发生和进展。本文将对PD提出的主要病因、星形胶质细胞控制这些病因的能力以及可用于促进星形胶质细胞神经保护作用的程序进行评论。
