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衰老和与年龄相关的脑疾病中的原发性纤毛和纤毛信号通路。

Primary cilia and ciliary signaling pathways in aging and age-related brain disorders.

机构信息

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA; Department of Anatomy, Physiology and Pharmacology, School of Veterinary Medicine, St. George's University, Grenada.

出版信息

Neurobiol Dis. 2022 Feb;163:105607. doi: 10.1016/j.nbd.2021.105607. Epub 2021 Dec 31.

DOI:10.1016/j.nbd.2021.105607
PMID:34979259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9280856/
Abstract

Brain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases. Emerging studies suggest that primary cilia could be a key regulator in brain diseases. The primary cilium is a singular cellular organelle expressed on the surface of many cell types, such as astrocytes and neurons in the mature brain. Primary cilia detect extracellular cues, such as Sonic Hedgehog (SHH) protein, and transduce these signals into cells to regulate various signaling pathways. Abnormalities in ciliary length and frequency (ratio of ciliated cells) have been implicated in various human diseases, including brain disorders. This review summarizes current findings and thoughts on the role of primary cilia and ciliary signaling pathways in aging and age-related brain disorders.

摘要

脑疾病的特征是由于神经细胞的进行性退化和/或死亡，导致大脑结构和功能的逐渐丧失。衰老 是脑疾病（如阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）和中风）的一个主要风险因素。多种细胞和分子事件已被证明在神经退行性疾病的进展中发挥作用。新兴的研究表明，初级纤毛可能是脑疾病的关键调节因子。初级纤毛是一种在成熟大脑中的许多细胞类型（如星形胶质细胞和神经元）表面表达的单一细胞细胞器。初级纤毛检测细胞外线索，如 Sonic Hedgehog（SHH）蛋白，并将这些信号转导到细胞中，以调节各种信号通路。纤毛长度和频率（有纤毛细胞的比例）的异常与各种人类疾病有关，包括脑疾病。本综述总结了目前关于初级纤毛和纤毛信号通路在衰老和与年龄相关的脑疾病中的作用的发现和思考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/ea26041bfd81/nihms-1820255-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/49dc9c3e8090/nihms-1820255-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/ea26041bfd81/nihms-1820255-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/49dc9c3e8090/nihms-1820255-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/314fdc5c0efc/nihms-1820255-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/284765d3b801/nihms-1820255-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/9280856/de5478b28ac9/nihms-1820255-f0004.jpg
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