Lee Song Yi, Nam Suyeong, Kim Sungyun, Koo Ja Seong, Hong In Kee, Kim Hill, Han Sangin, Kang Minji, Yang Heejung, Cho Hyun-Jong
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.
R&D Center, Radiant Ltd., Chuncheon, Gangwon 24398, Republic of Korea.
Evid Based Complement Alternat Med. 2018 Aug 19;2018:3610494. doi: 10.1155/2018/3610494. eCollection 2018.
A cream formulation containing (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 ( < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups ( < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment.
一种含有（AC）提取物（ACE）的乳膏制剂被开发用于银屑病治疗。尽管ACE可溶于有机溶剂，但其局部应用因毒性而受到限制。因此，开发了一种乳膏制剂，以便于将ACE安全地局部应用于皮肤病变处。使用咪喹莫特（IMQ）诱导的银屑病样小鼠模型评估了ACE乳膏的抗银屑病特性。在银屑病样小鼠模型中，第4天时，IMQ + ACE乳膏组的累积评分（发红、厚度和脱屑）显著低于其他组（<0.05）。皮肤组织苏木精和伊红染色结果显示，IMQ + ACE乳膏组的表皮厚度值显著低于其他实验组（<0.05）。细胞间黏附分子-1（ICAM-1）的表达水平表明白细胞浸润到皮肤中并随后与角质形成细胞相互作用，IMQ + ACE乳膏组中的该表达水平也低于IMQ组。这些结果表明，ACE乳膏制剂可安全、方便地用于银屑病治疗。
