Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas.

Colorectal cancer (CRC) is one of the world's leading causes of cancer-related deaths; thus, it is important to detect it as early as possible. Obesity is thought to be linked to a large rise in the CRC incidence as a result of bad dietary choices, such as a high intake of animal fats. Fatty acid-binding proteins (FABPs) are a set of molecules that coordinate intracellular lipid responses and are highly associated with metabolism and inflammatory pathways. There are nine types of genes that have been found in mammals, which are , , and . Each gene has its own roles in different organs of the body; hence, each one has different expression levels in different cancers. The roles of family genes in the development of CRC are still poorly understood. We used a bioinformatics approach to examine family gene expression profiles using the Oncomine, GEPIA, PrognoScan, STRING, cBioPortal, MetaCore, and TIMER platforms. Results showed that the messenger (m)RNA level is overexpressed in CRC cells compared to normal cells. The overexpression of was found to be related to poor prognosis in CRC patients' overall survival. The immunohistochemical results in the Human Protein Atlas showed that FABP1 and FABP6 exhibited strong staining in CRC tissues. An enrichment analysis showed that high expression of was significantly correlated with the role of microRNAs in cell proliferation in the development of CRC through the insulin-like growth factor (IGF) signaling pathway. functions as an intracellular bile-acid transporter in the ileal epithelium. We looked at expression in CRC since bile acids are important in the carcinogenesis of CRC. In conclusion, high expression is expected to be a potential biomarker for detecting CRC at the early stage.