Khan Faiz Ullah, Fang Yu
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China.
Center for Drug Safety and Policy Research, Xi'an Jiaotong University, Xi'an 710061, China.
Antibiotics (Basel). 2021 Sep 23;10(10):1147. doi: 10.3390/antibiotics10101147.
Globally, lower respiratory infections (LRTIs) are one of the most common infectious diseases whichaffect majority of the population and as a result of inappropriate antibiotics practices lead to antibiotic resistance (AR). An individual randomized control trial will be conducted in the post-conflict areas of Swat, Pakistan, through a random sampling method. Patients aged > 18 years will be recruited from five community pharmacies and assigned to equally sized groups to receive either pharmacist-led education interventions or usual care with no intervention. A total of 400 (control = 200, study = 200) patients will be included, with prescriptions comprised of antibiotics for LRTIs. The outcomes measured in both groups will be a combination of treatment cure rate and adherence, which will be assessed using the Morisky Medication Adherence Scale and pill count. The trial comprises pharmacist-led educational interventions to improve treatment outcomes for patients with LRTIs. This study might establish the groundwork for pharmaceutical care of LRTIs patients with antibacterial therapy and the future delivery of a care strategy for the improvement of LRTIs treatment outcomes in post-conflict, remote areas of the third world and LMICs.
在全球范围内，下呼吸道感染（LRTIs）是最常见的传染病之一，影响着大多数人口，并且由于不恰当的抗生素使用导致了抗生素耐药性（AR）。将通过随机抽样方法在巴基斯坦斯瓦特的冲突后地区进行一项个体随机对照试验。年龄大于18岁的患者将从五家社区药店招募，并被分配到同等规模的组中，分别接受药剂师主导的教育干预或无干预的常规护理。总共将纳入400名患者（对照组 = 200名，研究组 = 200名），其处方包括用于治疗下呼吸道感染的抗生素。两组中测量的结果将是治疗治愈率和依从性的综合指标，这将使用莫氏药物依从性量表和药丸计数来评估。该试验包括药剂师主导的教育干预，以改善下呼吸道感染患者的治疗效果。本研究可能为下呼吸道感染患者抗菌治疗的药学服务以及未来在冲突后第三世界偏远地区和低收入和中等收入国家改善下呼吸道感染治疗效果的护理策略奠定基础。
