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Tigecycline in the Treatment of Ventilator-Associated Pneumonia Due to Stenotrophomonas maltophilia: A Multicenter Retrospective Cohort Study.替加环素治疗嗜麦芽窄食单胞菌所致呼吸机相关性肺炎:一项多中心回顾性队列研究
Infect Dis Ther. 2021 Dec;10(4):2415-2429. doi: 10.1007/s40121-021-00516-5. Epub 2021 Aug 10.
2
Clinical outcomes of Stenotrophomonas maltophilia infection treated with trimethoprim/sulfamethoxazole, minocycline, or fluoroquinolone monotherapy.单用复方新诺明、米诺环素或氟喹诺酮治疗嗜麦芽窄食单胞菌感染的临床疗效。
Int J Antimicrob Agents. 2021 Aug;58(2):106367. doi: 10.1016/j.ijantimicag.2021.106367. Epub 2021 May 28.
3
Advances in the Microbiology of Stenotrophomonas maltophilia.嗜麦芽寡养单胞菌微生物学研究进展。
Clin Microbiol Rev. 2021 Jun 16;34(3):e0003019. doi: 10.1128/CMR.00030-19. Epub 2021 May 26.
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In vitro activity of cefiderocol and comparators against isolates of Gram-negative pathogens from a range of infection sources: SIDERO-WT-2014-2018 studies in Italy.在体外,头孢地尔罗与对照药物对来自不同感染源的革兰氏阴性病原体分离株的活性:SIDERO-WT-2014-2018 年意大利研究。
J Glob Antimicrob Resist. 2021 Jun;25:390-398. doi: 10.1016/j.jgar.2021.04.019. Epub 2021 May 18.
5
Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro.阿维巴坦增强了头孢他啶和氨曲南对体外嗜麦芽窄食单胞菌临床分离株的活性。
BMC Microbiol. 2021 Feb 22;21(1):60. doi: 10.1186/s12866-021-02108-2.
6
Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial.头孢地尔罗或最佳现有治疗方案治疗碳青霉烯类耐药革兰氏阴性菌引起的严重感染的疗效和安全性(CREDIBLE-CR):一项随机、开放标签、多中心、以病原体为重点、描述性的 3 期临床试验。
Lancet Infect Dis. 2021 Feb;21(2):226-240. doi: 10.1016/S1473-3099(20)30796-9. Epub 2020 Oct 12.
7
Activity of Aztreonam in Combination with Avibactam, Clavulanate, Relebactam, and Vaborbactam against Multidrug-Resistant Stenotrophomonas maltophilia.头孢他啶阿维巴坦、克拉维酸、雷利巴坦和沃博巴坦对多重耐药嗜麦芽窄食单胞菌的活性。
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8
Isolation and Characterization of the Novel Bacteriophage AXL3 against .分离并鉴定新型噬菌体 AXL3 对 。
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Treatment options for K. pneumoniae, P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach based on the mechanisms of resistance to carbapenems.碳青霉烯类、氨基糖苷类、多黏菌素类和替加环素耐药的肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌的治疗选择:基于碳青霉烯类耐药机制的方法。
Infection. 2020 Dec;48(6):835-851. doi: 10.1007/s15010-020-01520-6. Epub 2020 Sep 1.
10
Cefiderocol Antimicrobial Susceptibility Testing Considerations: the Achilles' Heel of the Trojan Horse?头孢地尔抗菌药物敏感性试验的考量:特洛伊木马的阿喀琉斯之踵?
J Clin Microbiol. 2020 Dec 17;59(1). doi: 10.1128/JCM.00951-20.

抗菌治疗策略:聚焦新型疗法

Antimicrobial Treatment Strategies for : A Focus on Novel Therapies.

作者信息

Gibb Jean, Wong Darren W

机构信息

Division of Infectious Diseases, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA 90033, USA.

出版信息

Antibiotics (Basel). 2021 Oct 9;10(10):1226. doi: 10.3390/antibiotics10101226.

DOI:10.3390/antibiotics10101226
PMID:34680807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8532924/
Abstract

is an urgent global threat due to its increasing incidence and intrinsic antibiotic resistance. Antibiotic development has focused on carbapenem-resistant Enterobacteriaceae, Pseudomonas, and Acinetobacter, with approved antibiotics in recent years having limited activity for Stenotrophomonas. Accordingly, novel treatment strategies for Stenotrophomonas are desperately needed. We conducted a systemic literature review and offer recommendations based on current evidence for a treatment strategy of Stenotrophomonas infection.

摘要

由于其发病率不断上升以及固有的抗生素耐药性,它已成为全球紧迫的威胁。抗生素研发主要集中在耐碳青霉烯类肠杆菌科细菌、铜绿假单胞菌和不动杆菌,近年来获批的抗生素对嗜麦芽窄食单胞菌的活性有限。因此,迫切需要针对嗜麦芽窄食单胞菌的新型治疗策略。我们进行了一项系统的文献综述,并根据当前证据对嗜麦芽窄食单胞菌感染的治疗策略提出建议。