Stamatiou Konstantinos, Samara Evangelia, Alidjanov Jakhongir F, Pilatz Adrian M E, Naber Kurt G, Wagenlehner Florian M E
Department of Urology, Tzaneio General Hospital, 18536 Piraeus, Greece.
Department of Anesthesiology and Pain Management, Tzaneio General Hospital, 18536 Piraeus, Greece.
Antibiotics (Basel). 2021 Oct 15;10(10):1253. doi: 10.3390/antibiotics10101253.
The Acute Cystitis Symptom Score (ACSS) is a patient self-reporting questionnaire for the clinical diagnosis and patient-reported outcome (PRO) in women with acute uncomplicated cystitis (AC). The aim of the current study (part II) is the clinical validation of the Greek ACSS questionnaire. After linguistic validation according to internationally accepted guidelines and cognitive assessment (part I), the clinical validation was performed by using the Greek ACSS study version in 92 evaluable female participants including 53 patients with symptoms suspicious of AC and 39 controls. The clinical outcome using the ACSS questionnaire at different points in time after the start of treatment was demonstrated as well. The age (mean ± SD) of the 53 patients (44.7 ± 17.0 years) and 39 controls (49.3 ± 15.9 years) and their additional conditions at baseline visits, such as menstruation, premenstrual syndrome, pregnancy, menopause, diabetes mellitus, were comparable. There was, however, a significant difference ( < 0.001) between patients and controls at baseline visit regarding sum score of the ACSS domains, such as typical symptoms and quality of life. The clinical outcome of up to 7 days showed a fast reduction of the symptom scores and improvement of quality of life. The optimal thresholds for the patient-reported outcome of successful therapy could be established. The linguistically and clinically validated Greek ACSS questionnaire can now be used for clinical or epidemiological studies and also for patients' self-diagnosis of AC and as a PRO measure tool.
急性膀胱炎症状评分（ACSS）是一种患者自我报告问卷，用于急性单纯性膀胱炎（AC）女性患者的临床诊断和患者报告结局（PRO）评估。本研究（第二部分）的目的是对希腊语版ACSS问卷进行临床验证。在根据国际认可的指南进行语言验证和认知评估（第一部分）之后，使用希腊语版ACSS研究版本对92名可评估的女性参与者进行了临床验证，其中包括53名有AC可疑症状的患者和39名对照。同时还展示了在治疗开始后不同时间点使用ACSS问卷得出的临床结局。53名患者（44.7±17.0岁）和39名对照（49.3±15.9岁）的年龄及其在基线访视时的其他状况，如月经、经前综合征、妊娠、绝经、糖尿病等，具有可比性。然而，在基线访视时，患者和对照在ACSS各领域的总分，如典型症状和生活质量方面存在显著差异（<0.001）。长达7天的临床结局显示症状评分快速降低，生活质量得到改善。可以确定成功治疗的患者报告结局的最佳阈值。经过语言和临床验证的希腊语版ACSS问卷现在可用于临床或流行病学研究，也可用于患者对AC的自我诊断以及作为一种PRO测量工具。
