Wu Ya-Ke, Brownley Kimberly A, Bardone-Cone Anna M, Bulik Cynthia M, Baker Jessica H
School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
J Pers Med. 2021 Oct 12;11(10):1020. doi: 10.3390/jpm11101020.
Binge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this exploratory study of 73 females with AN were: (1) to examine changes in cortisol, the adrenocorticotropic hormone, norepinephrine, ghrelin (total and active), and leptin levels across the admission, discharge, and 3 months post-discharge from the inpatient AN weight restoration; and (2) to determine whether the target hormones were associated with objective or subjective binge eating (OBE or SBE). The participants completed the self-reported Eating Disorder Examination Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory-II, and provided fasting whole blood samples for hormone assays. The results showed significant changes in body mass index (BMI), cortisol, total ghrelin, and leptin levels over the three time points. The cortisol levels at admission and discharge were significantly associated with the number of SBE episodes at 3 months post-discharge. Findings suggest the need to replicate and confirm the role of cortisol in predicting the emergence of SBE and uncover the mechanisms underlying SBE and cortisol to prevent SBE and its negative consequences.
暴饮暴食是一种跨诊断的饮食失调症状，可发生在神经性厌食症（AN）患者中，在体重恢复后持续存在，并阻碍其康复。然而，对于AN体重恢复后暴饮暴食的生物学预测因素知之甚少。这项对73名患有AN的女性进行的探索性研究的目标是：（1）检查住院AN体重恢复期间入院、出院时以及出院后3个月时皮质醇、促肾上腺皮质激素、去甲肾上腺素、胃饥饿素（总胃饥饿素和活性胃饥饿素）和瘦素水平的变化；（2）确定目标激素是否与客观或主观暴饮暴食（OBE或SBE）相关。参与者完成了自我报告的饮食失调检查问卷、贝克焦虑量表和贝克抑郁量表-II，并提供空腹全血样本进行激素检测。结果显示，在三个时间点上，体重指数（BMI）、皮质醇、总胃饥饿素和瘦素水平有显著变化。入院时和出院时的皮质醇水平与出院后3个月时的SBE发作次数显著相关。研究结果表明，需要重复并确认皮质醇在预测SBE出现中的作用，并揭示SBE和皮质醇背后的机制，以预防SBE及其负面后果。
